Dysfunctional Changes in the Lens in Real Clinical Practice
Introduction. Presbyopia is a global problem affecting more than 1.5 billion people worldwide. Projections indicate an increase in the average age of the population to 40 years by 2050, which is associated with an increase in the presbyopia incidence and corresponding economic losses. Despite the wi...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2024-10-01
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| Series: | Oftalʹmologiâ |
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| Online Access: | https://www.ophthalmojournal.com/opht/article/view/2444 |
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| author | A. Zh. Fursova I. A. Loskutov F. G. Borisov |
| author_facet | A. Zh. Fursova I. A. Loskutov F. G. Borisov |
| author_sort | A. Zh. Fursova |
| collection | DOAJ |
| description | Introduction. Presbyopia is a global problem affecting more than 1.5 billion people worldwide. Projections indicate an increase in the average age of the population to 40 years by 2050, which is associated with an increase in the presbyopia incidence and corresponding economic losses. Despite the widespread prevalence of presbyopia, there are currently no effective methods for early prevention and restoration of dynamic accommodation and a standardized approach to assessing age-related changes in the lens that underlie presbyopia. The purpose: to study the effect of age-related changes in the lens on accommodation and to consider modern pharmacological approaches to the prevention and treatment of presbyopia.Methods. A multicenter prospective study was conducted, including analysis of visual acuity, the nearest point of clear vision and the volume of accommodation in individuals aged 40 to 55 years. Study participants were prescribed pyrenoxine (Catalin) as eye drops three times daily for 4 months. The study included 382 questionnaires collected from 29 ophthalmologists.Results. As a result of the study, the average distance to the nearest point of clear vision decreased slightly, but the reserve of accommodation remained at the same level. This indicates the absence of significant progression of age-related decrease in the reserve of accommodation as one of the manifestations of presbyopia and the possible effectiveness of pyrenoxine in preserving the elastic properties of the lens.Conclusion. The study confirmed the effectiveness of pyrenoxine in the prevention of presbyopia and the preservation of accommodative abilities in middle-aged people. The concept of Dysfunctional Lens Syndrome may be useful for clinical practice by providing opportunities for early diagnosis and treatment of presbyopia. Incorporating this concept into clinical guidelines may improve approaches to the treatment and prevention of age-related lens changes. |
| format | Article |
| id | doaj-art-ca781955d48342a9ad1c70de54130a9f |
| institution | Kabale University |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2024-10-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-ca781955d48342a9ad1c70de54130a9f2025-08-20T04:00:20ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452024-10-0121361762210.18008/1816-5095-2024-3-617-6221186Dysfunctional Changes in the Lens in Real Clinical PracticeA. Zh. Fursova0I. A. Loskutov1F. G. Borisov2State Novosibirsk Regional Clinical Hospital; Novosibirsk State Medical UniversityMoscow Regional Research Clinical Institute named after M.F. VladimirskyMoscow Regional Research Clinical Institute named after M.F. VladimirskyIntroduction. Presbyopia is a global problem affecting more than 1.5 billion people worldwide. Projections indicate an increase in the average age of the population to 40 years by 2050, which is associated with an increase in the presbyopia incidence and corresponding economic losses. Despite the widespread prevalence of presbyopia, there are currently no effective methods for early prevention and restoration of dynamic accommodation and a standardized approach to assessing age-related changes in the lens that underlie presbyopia. The purpose: to study the effect of age-related changes in the lens on accommodation and to consider modern pharmacological approaches to the prevention and treatment of presbyopia.Methods. A multicenter prospective study was conducted, including analysis of visual acuity, the nearest point of clear vision and the volume of accommodation in individuals aged 40 to 55 years. Study participants were prescribed pyrenoxine (Catalin) as eye drops three times daily for 4 months. The study included 382 questionnaires collected from 29 ophthalmologists.Results. As a result of the study, the average distance to the nearest point of clear vision decreased slightly, but the reserve of accommodation remained at the same level. This indicates the absence of significant progression of age-related decrease in the reserve of accommodation as one of the manifestations of presbyopia and the possible effectiveness of pyrenoxine in preserving the elastic properties of the lens.Conclusion. The study confirmed the effectiveness of pyrenoxine in the prevention of presbyopia and the preservation of accommodative abilities in middle-aged people. The concept of Dysfunctional Lens Syndrome may be useful for clinical practice by providing opportunities for early diagnosis and treatment of presbyopia. Incorporating this concept into clinical guidelines may improve approaches to the treatment and prevention of age-related lens changes.https://www.ophthalmojournal.com/opht/article/view/2444lens dysfunction syndromevolume of accommodationpyrenoxinepresbyopiacataract |
| spellingShingle | A. Zh. Fursova I. A. Loskutov F. G. Borisov Dysfunctional Changes in the Lens in Real Clinical Practice Oftalʹmologiâ lens dysfunction syndrome volume of accommodation pyrenoxine presbyopia cataract |
| title | Dysfunctional Changes in the Lens in Real Clinical Practice |
| title_full | Dysfunctional Changes in the Lens in Real Clinical Practice |
| title_fullStr | Dysfunctional Changes in the Lens in Real Clinical Practice |
| title_full_unstemmed | Dysfunctional Changes in the Lens in Real Clinical Practice |
| title_short | Dysfunctional Changes in the Lens in Real Clinical Practice |
| title_sort | dysfunctional changes in the lens in real clinical practice |
| topic | lens dysfunction syndrome volume of accommodation pyrenoxine presbyopia cataract |
| url | https://www.ophthalmojournal.com/opht/article/view/2444 |
| work_keys_str_mv | AT azhfursova dysfunctionalchangesinthelensinrealclinicalpractice AT ialoskutov dysfunctionalchangesinthelensinrealclinicalpractice AT fgborisov dysfunctionalchangesinthelensinrealclinicalpractice |