Optimizing UK biobank cloud-based research analysis platform to fine-map coronary artery disease loci in whole genome sequencing data

Optimizing UK biobank cloud-based research analysis platform to fine-map coronary artery disease loci in whole genome sequencing data

Abstract We conducted the first comprehensive association analysis of a coronary artery disease (CAD) cohort within the recently released UK Biobank (UKB) whole genome sequencing dataset. We employed fine mapping tool PolyFun and pinpoint rs10757274 as the most likely causal SNV within the 9p21.3 CA...

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Bibliographic Details
Main Authors: Letitia M.F. Sng, Anubhav Kaphle, Mitchell J. O’Brien, Brendan Hosking, Roc Reguant, Johan Verjans, Yatish Jain, Natalie A. Twine, Denis C. Bauer
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Population-scale genetics
UK Biobank
DNAnexus
Cloud-computing
GWAS
Trusted research environments
Online Access:https://doi.org/10.1038/s41598-025-95286-2
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