Intersegment Recombination During Influenza A Virus Replication Gives Rise to a Novel Class of Defective Viral Genomes

Intersegment Recombination During Influenza A Virus Replication Gives Rise to a Novel Class of Defective Viral Genomes

Influenza A virus (IAV) is a highly diverse pathogen with genetic variability primarily driven by mutation and reassortment. Using next-generation sequencing (NGS), we characterised defective viral genomes (DVGs) generated during the serial passaging of influenza A/Puerto Rico/8/1934 (H1N1) virus in...

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Bibliographic Details
Main Authors: Soraya Anisi, George Noble, Rory Williams, Jack Hales, Hannah E. Bridgewater, Andrew Easton, William Collier, Phillip Gould
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Viruses
Subjects:
influenza A virus
defective viral genomes
RNA recombination
next-generation sequencing
multisegment recombination
viral evolution
Online Access:https://www.mdpi.com/1999-4915/17/6/856
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