Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties
Intracellular trafficking supports all cell functions maintaining the exchange of material between membrane-bound organelles and the plasma membrane during endocytosis, cargo sorting, and exocytosis/secretion. Several proteins of the intracellular trafficking machinery are deregulated in diseases, p...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1491304/full |
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| author | Julie Patat Kristine Schauer Kristine Schauer Hugo Lachuer |
| author_facet | Julie Patat Kristine Schauer Kristine Schauer Hugo Lachuer |
| author_sort | Julie Patat |
| collection | DOAJ |
| description | Intracellular trafficking supports all cell functions maintaining the exchange of material between membrane-bound organelles and the plasma membrane during endocytosis, cargo sorting, and exocytosis/secretion. Several proteins of the intracellular trafficking machinery are deregulated in diseases, particularly cancer. This complex and deadly disease stays a heavy burden for society, despite years of intense research activity. Here, we give an overview about trafficking proteins and highlight that in addition to their molecular functions, they contribute to the emergence of intracellular organelle landscapes. We review recent evidence of organelle landscape alterations in cancer. We argue that focusing on organelles, which represent the higher-order, cumulative behavior of trafficking regulators, could help to better understand, describe and fight cancer. In particular, we propose adopting a physical framework to describe the organelle landscape, with the goal of identifying the key parameters that are crucial for a stable and non-random organelle organization characteristic of healthy cells. By understanding these parameters, we may gain insights into the mechanisms that lead to a pathological organelle spatial organization, which could help explain the plasticity of cancer cells. |
| format | Article |
| id | doaj-art-ca7382a0ed194568bccea26b53ccaa15 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-ca7382a0ed194568bccea26b53ccaa152025-01-20T07:19:44ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-01-011210.3389/fcell.2024.14913041491304Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical propertiesJulie Patat0Kristine Schauer1Kristine Schauer2Hugo Lachuer3Cell Biology of Organelle Networks Team, Tumor Cell Dynamics Unit, Inserm U1279 Gustave Roussy Institute, Université Paris-Saclay, Villejuif, FranceCell Biology of Organelle Networks Team, Tumor Cell Dynamics Unit, Inserm U1279 Gustave Roussy Institute, Université Paris-Saclay, Villejuif, FranceCentre National de la Recherche Scientifique (CNRS), Paris, FranceInstitut Jacques Monod, Université de Paris, Paris, FranceIntracellular trafficking supports all cell functions maintaining the exchange of material between membrane-bound organelles and the plasma membrane during endocytosis, cargo sorting, and exocytosis/secretion. Several proteins of the intracellular trafficking machinery are deregulated in diseases, particularly cancer. This complex and deadly disease stays a heavy burden for society, despite years of intense research activity. Here, we give an overview about trafficking proteins and highlight that in addition to their molecular functions, they contribute to the emergence of intracellular organelle landscapes. We review recent evidence of organelle landscape alterations in cancer. We argue that focusing on organelles, which represent the higher-order, cumulative behavior of trafficking regulators, could help to better understand, describe and fight cancer. In particular, we propose adopting a physical framework to describe the organelle landscape, with the goal of identifying the key parameters that are crucial for a stable and non-random organelle organization characteristic of healthy cells. By understanding these parameters, we may gain insights into the mechanisms that lead to a pathological organelle spatial organization, which could help explain the plasticity of cancer cells.https://www.frontiersin.org/articles/10.3389/fcell.2024.1491304/fullorganelle distributionself-organizationnon-random positioningnon-equilibrium steady-state (NESS)lysosomes |
| spellingShingle | Julie Patat Kristine Schauer Kristine Schauer Hugo Lachuer Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties Frontiers in Cell and Developmental Biology organelle distribution self-organization non-random positioning non-equilibrium steady-state (NESS) lysosomes |
| title | Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties |
| title_full | Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties |
| title_fullStr | Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties |
| title_full_unstemmed | Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties |
| title_short | Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties |
| title_sort | trafficking in cancer from gene deregulation to altered organelles and emerging biophysical properties |
| topic | organelle distribution self-organization non-random positioning non-equilibrium steady-state (NESS) lysosomes |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1491304/full |
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