Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi-experimental study
Objective To evaluate knowledge of antimicrobial resistance (AMR), to study how the judgement of health value (HVJ) and economic value (EVJ) affects antibiotic use, and to understand if access to information on AMR implications may influence perceived AMR mitigation strategies.Design A quasi-experim...
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BMJ Publishing Group
2023-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/13/2/e065233.full |
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| author | Ulrika Enemark Evans Otieku Ama Pokuaa Fenny Alex Kwame Owusu-Ofori Appiah-Koran Labi Jørgen Kurtzhals |
| author_facet | Ulrika Enemark Evans Otieku Ama Pokuaa Fenny Alex Kwame Owusu-Ofori Appiah-Koran Labi Jørgen Kurtzhals |
| author_sort | Ulrika Enemark |
| collection | DOAJ |
| description | Objective To evaluate knowledge of antimicrobial resistance (AMR), to study how the judgement of health value (HVJ) and economic value (EVJ) affects antibiotic use, and to understand if access to information on AMR implications may influence perceived AMR mitigation strategies.Design A quasi-experimental study with interviews performed before and after an intervention where hospital staff collected data and provided one group of participants with information about the health and economic implications of antibiotic use and resistance compared with a control group not receiving the intervention.Setting Korle-Bu and Komfo Anokye Teaching Hospitals, Ghana.Participants Adult patients aged 18 years and older seeking outpatient care.Main outcome measures We measured three outcomes: (1) level of knowledge of the health and economic implications of AMR; (2) HVJ and EVJ behaviours influencing antibiotic use and (3) differences in perceived AMR mitigation strategy between participants exposed and not exposed to the intervention.Results Most participants had a general knowledge of the health and economic implications of antibiotic use and AMR. Nonetheless, a sizeable proportion disagreed or disagreed to some extent that AMR may lead to reduced productivity/indirect costs (71% (95% CI 66% to 76%)), increased provider costs (87% (95% CI 84% to 91%)) and costs for carers of AMR patients/societal costs (59% (95% CI 53% to 64%)). Both HVJ-driven and EVJ-driven behaviours influenced antibiotic use, but the latter was a better predictor (reliability coefficient >0.87). Compared with the unexposed group, participants exposed to the intervention were more likely to recommend restrictive access to antibiotics (p<0.01) and pay slightly more for a health treatment strategy to reduce their risk of AMR (p<0.01).Conclusion There is a knowledge gap about antibiotic use and the implications of AMR. Access to AMR information at the point of care could be a successful way to mitigate the prevalence and implications of AMR. |
| format | Article |
| id | doaj-art-ca71be01075e4deaa2e15ad2b1f839ef |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-ca71be01075e4deaa2e15ad2b1f839ef2025-08-20T03:15:26ZengBMJ Publishing GroupBMJ Open2044-60552023-02-0113210.1136/bmjopen-2022-065233Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi-experimental studyUlrika Enemark0Evans Otieku1Ama Pokuaa Fenny2Alex Kwame Owusu-Ofori3Appiah-Koran Labi4Jørgen Kurtzhals5Department of Public Health, Aarhus University, Aarhus, DenmarkEconomics Division, Institute of Statistical, Social, and Economic Research (ISSER), University of Ghana, Legon, GhanaEconomics Division, Institute of Statistical, Social, and Economic Research (ISSER), University of Ghana, Legon, GhanaLaboratory Services Directorate, Komfo Anokye Teaching Hospital, Kumasi, GhanaDepartment of Medical Microbiology, University of Ghana Medical School, Accra, GhanaDepartment of Clinical Microbiology, Rigshospitalet, Copenhagen, DenmarkObjective To evaluate knowledge of antimicrobial resistance (AMR), to study how the judgement of health value (HVJ) and economic value (EVJ) affects antibiotic use, and to understand if access to information on AMR implications may influence perceived AMR mitigation strategies.Design A quasi-experimental study with interviews performed before and after an intervention where hospital staff collected data and provided one group of participants with information about the health and economic implications of antibiotic use and resistance compared with a control group not receiving the intervention.Setting Korle-Bu and Komfo Anokye Teaching Hospitals, Ghana.Participants Adult patients aged 18 years and older seeking outpatient care.Main outcome measures We measured three outcomes: (1) level of knowledge of the health and economic implications of AMR; (2) HVJ and EVJ behaviours influencing antibiotic use and (3) differences in perceived AMR mitigation strategy between participants exposed and not exposed to the intervention.Results Most participants had a general knowledge of the health and economic implications of antibiotic use and AMR. Nonetheless, a sizeable proportion disagreed or disagreed to some extent that AMR may lead to reduced productivity/indirect costs (71% (95% CI 66% to 76%)), increased provider costs (87% (95% CI 84% to 91%)) and costs for carers of AMR patients/societal costs (59% (95% CI 53% to 64%)). Both HVJ-driven and EVJ-driven behaviours influenced antibiotic use, but the latter was a better predictor (reliability coefficient >0.87). Compared with the unexposed group, participants exposed to the intervention were more likely to recommend restrictive access to antibiotics (p<0.01) and pay slightly more for a health treatment strategy to reduce their risk of AMR (p<0.01).Conclusion There is a knowledge gap about antibiotic use and the implications of AMR. Access to AMR information at the point of care could be a successful way to mitigate the prevalence and implications of AMR.https://bmjopen.bmj.com/content/13/2/e065233.full |
| spellingShingle | Ulrika Enemark Evans Otieku Ama Pokuaa Fenny Alex Kwame Owusu-Ofori Appiah-Koran Labi Jørgen Kurtzhals Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi-experimental study BMJ Open |
| title | Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi-experimental study |
| title_full | Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi-experimental study |
| title_fullStr | Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi-experimental study |
| title_full_unstemmed | Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi-experimental study |
| title_short | Knowledge, attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in Ghana: a quasi-experimental study |
| title_sort | knowledge attitudes and practices regarding antimicrobial use and resistance among healthcare seekers in two tertiary hospitals in ghana a quasi experimental study |
| url | https://bmjopen.bmj.com/content/13/2/e065233.full |
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