Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage
Dendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate self-antigens. Since DCs can be modulated dependi...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/856707 |
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| author | Priscila de Matos Silva Julia Bier Lisiery Negrini Paiatto Cassia Galdino Albuquerque Caique Lopes Souza Luis Gustavo Romani Fernandes Wirla Maria da Silva Cunha Tamashiro Patricia Ucelli Simioni |
| author_facet | Priscila de Matos Silva Julia Bier Lisiery Negrini Paiatto Cassia Galdino Albuquerque Caique Lopes Souza Luis Gustavo Romani Fernandes Wirla Maria da Silva Cunha Tamashiro Patricia Ucelli Simioni |
| author_sort | Priscila de Matos Silva |
| collection | DOAJ |
| description | Dendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate self-antigens. Since DCs can be modulated depending on the surrounding microenvironment, they can act as a bridge between innate and adaptive immunity. However, the mechanisms that support this dual role are not entirely clear. Recent studies have shown that DCs can be manipulated ex vivo in order to trigger their tolerogenic profile, what can be a tool to be used in clinical trials aiming the treatment of various diseases and the prevention of transplant rejection. In this sense, the blockage of costimulatory molecules on DC, in the attempt of inhibiting the second signal in the immunological synapse, can be considered as one of the main strategies under development. This review brings an update on current therapies using tolerogenic dendritic cells modulated with costimulatory blockers with the aim of reducing transplant rejection. However, although there are current clinical trials using tolerogenic DC to treat allograft rejection, the actual challenge is to modulate these cells in order to maintain a permanent tolerogenic profile. |
| format | Article |
| id | doaj-art-ca6ca9fef964445db936540eeac6da09 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-ca6ca9fef964445db936540eeac6da092025-08-20T02:19:47ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/856707856707Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal BlockagePriscila de Matos Silva0Julia Bier1Lisiery Negrini Paiatto2Cassia Galdino Albuquerque3Caique Lopes Souza4Luis Gustavo Romani Fernandes5Wirla Maria da Silva Cunha Tamashiro6Patricia Ucelli Simioni7Department of Biomedical Science, Faculty of Americana (FAM), 13477-360 Americana, SP, BrazilDepartment of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Biomedical Science, Faculty of Americana (FAM), 13477-360 Americana, SP, BrazilDepartment of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Biomedical Science, Faculty of Americana (FAM), 13477-360 Americana, SP, BrazilDepartment of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Biomedical Science, Faculty of Americana (FAM), 13477-360 Americana, SP, BrazilDendritic cells (DCs), the most important professional antigen-presenting cells (APC), play crucial role in both immunity and tolerance. It is well known that DCs are able to mount immune responses against foreign antigens and simultaneously tolerate self-antigens. Since DCs can be modulated depending on the surrounding microenvironment, they can act as a bridge between innate and adaptive immunity. However, the mechanisms that support this dual role are not entirely clear. Recent studies have shown that DCs can be manipulated ex vivo in order to trigger their tolerogenic profile, what can be a tool to be used in clinical trials aiming the treatment of various diseases and the prevention of transplant rejection. In this sense, the blockage of costimulatory molecules on DC, in the attempt of inhibiting the second signal in the immunological synapse, can be considered as one of the main strategies under development. This review brings an update on current therapies using tolerogenic dendritic cells modulated with costimulatory blockers with the aim of reducing transplant rejection. However, although there are current clinical trials using tolerogenic DC to treat allograft rejection, the actual challenge is to modulate these cells in order to maintain a permanent tolerogenic profile.http://dx.doi.org/10.1155/2015/856707 |
| spellingShingle | Priscila de Matos Silva Julia Bier Lisiery Negrini Paiatto Cassia Galdino Albuquerque Caique Lopes Souza Luis Gustavo Romani Fernandes Wirla Maria da Silva Cunha Tamashiro Patricia Ucelli Simioni Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage Journal of Immunology Research |
| title | Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage |
| title_full | Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage |
| title_fullStr | Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage |
| title_full_unstemmed | Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage |
| title_short | Tolerogenic Dendritic Cells on Transplantation: Immunotherapy Based on Second Signal Blockage |
| title_sort | tolerogenic dendritic cells on transplantation immunotherapy based on second signal blockage |
| url | http://dx.doi.org/10.1155/2015/856707 |
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