PET imaging of functional 5-HT1A receptors with [18F]F13640: From PET kinetics modeling to static Standardized Uptake Values Ratio

PET imaging of functional 5-HT1A receptors with [18F]F13640: From PET kinetics modeling to static Standardized Uptake Values Ratio

Purpose: F13640 is a highly selective serotonin 5-HT1A receptor ligand with agonist properties identified as a PET radiopharmaceutical candidate. In previous work, we showed the possibility to use long dynamic PET acquisition (225 min) combined with simplified kinetic modelling for [18F]F13640 quant...

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Bibliographic Details
Main Authors: Pierre Courault, Inés Mérida, Nicolas Costes, Jérôme Redoute, Luc Zimmer, Sophie Lancelot
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:NeuroImage
Subjects:
5-HT1A receptor
[18F]F13640
Static acquisition
SUVR quantification
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811925001120
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