Targeting tumor-intrinsic S100 calcium-binding protein A1 augments antitumor immunity and potentiates immunotherapy efficacy

Abstract Immune checkpoint blockade (ICB) has revolutionized cancer treatment, but the therapeutic response is highly heterogeneous, which highlights the necessity for developing predictive biomarkers and overcoming ICB resistance. Cancer cell-intrinsic features, especially those that can be dynamic...

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Bibliographic Details
Main Authors: Yufeng Guo, Rui Wan, Jianchun Duan, Li Yuan, Zhijie Wang, Jia Zhong, Xue Zhang, Zixiao Ma, Hua Bai, Jie Wang
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02190-2
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