Association between visceral fat and bone mineral density in perimenopausal women
Background The effects of visceral fat and body fat on osteoporosis (OP) have long been controversial. This study investigated the correlation between visceral fat and bone mineral density (BMD) in perimenopausal women aged 40–60. The goal was to evaluate the current state of BMD and its influencing...
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PeerJ Inc.
2025-02-01
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| author | Xu Tang Ling Tang Xiaolin Li Jiejing Cao Huanhuan Wang Shujiao Liu Yufang Yi Zhiyong Zhang |
| author_facet | Xu Tang Ling Tang Xiaolin Li Jiejing Cao Huanhuan Wang Shujiao Liu Yufang Yi Zhiyong Zhang |
| author_sort | Xu Tang |
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| description | Background The effects of visceral fat and body fat on osteoporosis (OP) have long been controversial. This study investigated the correlation between visceral fat and bone mineral density (BMD) in perimenopausal women aged 40–60. The goal was to evaluate the current state of BMD and its influencing factors, with the specific objective of establishing a foundation for preventing and treating osteoporosis in this demographic. Methods This case-control study included female participants (n = 330), aged 40–60 years, from the Health Management Center of Guilin Medical College Affiliated Hospital, China, between January 2020 to August 2023. Their BMD was assessed using an ultrasound bone mineral density meter, and the visceral fat area was determined utilizing a body composition analyzer. Furthermore, past medical history, dietary habits, and lifestyle factors were collected through a telephonic questionnaire survey. Additionally, we analyzed the baseline characteristics of the population, bone status and visceral fat status, and the relationship between these variables. Results Among perimenopausal women with varying bone mineral density statuses, there was no significant difference regarding body fat percentage (p = 0.359). In contrast, a statistically significant difference was observed regarding visceral fat area (p < 0.001) and vitamin D (p < 0.001). The visceral fat area exhibited an inverse correlation with bone density (r = –0.313, p < 0.001). Additionally, mediation analysis outcomes did not support the hypothesis that visceral fat affects bone density through its influence on vitamin D levels (p = 0.92). Conclusions Among perimenopausal women, visceral fat is negatively associated with bone density, suggesting that the distribution of body fat rather than the total amount plays a pivotal role in the development of osteoporosis. These findings suggest the significance of regular physical exercise and the abdominal fat distribution for perimenopausal women. |
| format | Article |
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| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-ca68d2e6572c457887aae5cffc9e1cfa2025-08-20T03:11:39ZengPeerJ Inc.PeerJ2167-83592025-02-0113e1895710.7717/peerj.18957Association between visceral fat and bone mineral density in perimenopausal womenXu Tang0Ling Tang1Xiaolin Li2Jiejing Cao3Huanhuan Wang4Shujiao Liu5Yufang Yi6Zhiyong Zhang7Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of General Medicine, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, ChinaDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi, ChinaDepartment of General Medicine, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, ChinaDepartment of General Medicine, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, ChinaDepartment of General Medicine, Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, ChinaDepartment of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi, ChinaBackground The effects of visceral fat and body fat on osteoporosis (OP) have long been controversial. This study investigated the correlation between visceral fat and bone mineral density (BMD) in perimenopausal women aged 40–60. The goal was to evaluate the current state of BMD and its influencing factors, with the specific objective of establishing a foundation for preventing and treating osteoporosis in this demographic. Methods This case-control study included female participants (n = 330), aged 40–60 years, from the Health Management Center of Guilin Medical College Affiliated Hospital, China, between January 2020 to August 2023. Their BMD was assessed using an ultrasound bone mineral density meter, and the visceral fat area was determined utilizing a body composition analyzer. Furthermore, past medical history, dietary habits, and lifestyle factors were collected through a telephonic questionnaire survey. Additionally, we analyzed the baseline characteristics of the population, bone status and visceral fat status, and the relationship between these variables. Results Among perimenopausal women with varying bone mineral density statuses, there was no significant difference regarding body fat percentage (p = 0.359). In contrast, a statistically significant difference was observed regarding visceral fat area (p < 0.001) and vitamin D (p < 0.001). The visceral fat area exhibited an inverse correlation with bone density (r = –0.313, p < 0.001). Additionally, mediation analysis outcomes did not support the hypothesis that visceral fat affects bone density through its influence on vitamin D levels (p = 0.92). Conclusions Among perimenopausal women, visceral fat is negatively associated with bone density, suggesting that the distribution of body fat rather than the total amount plays a pivotal role in the development of osteoporosis. These findings suggest the significance of regular physical exercise and the abdominal fat distribution for perimenopausal women.https://peerj.com/articles/18957.pdfVisceral fatPerimenopausalBone mineral densityVitamin DOsteoporosis |
| spellingShingle | Xu Tang Ling Tang Xiaolin Li Jiejing Cao Huanhuan Wang Shujiao Liu Yufang Yi Zhiyong Zhang Association between visceral fat and bone mineral density in perimenopausal women PeerJ Visceral fat Perimenopausal Bone mineral density Vitamin D Osteoporosis |
| title | Association between visceral fat and bone mineral density in perimenopausal women |
| title_full | Association between visceral fat and bone mineral density in perimenopausal women |
| title_fullStr | Association between visceral fat and bone mineral density in perimenopausal women |
| title_full_unstemmed | Association between visceral fat and bone mineral density in perimenopausal women |
| title_short | Association between visceral fat and bone mineral density in perimenopausal women |
| title_sort | association between visceral fat and bone mineral density in perimenopausal women |
| topic | Visceral fat Perimenopausal Bone mineral density Vitamin D Osteoporosis |
| url | https://peerj.com/articles/18957.pdf |
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