Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant Staphylococci
The growing threat of proliferation of biofilm-forming hospital strains of coagulase-negative staphylococci resistant to antibiotics determines the need for an urgent search for new effective antibacterial compounds, as well as the development of methods for the combined use of traditional and alter...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-08-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/734 |
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| author | L. I. Kononova I. A. Pyankov A. A. Smolyak Yu. V. Shklyaev V. P. Korobov |
| author_facet | L. I. Kononova I. A. Pyankov A. A. Smolyak Yu. V. Shklyaev V. P. Korobov |
| author_sort | L. I. Kononova |
| collection | DOAJ |
| description | The growing threat of proliferation of biofilm-forming hospital strains of coagulase-negative staphylococci resistant to antibiotics determines the need for an urgent search for new effective antibacterial compounds, as well as the development of methods for the combined use of traditional and alternative antibiotics. The article presents the results of a study of the combined effect of the drug «SA» — a new synthetic derivative of the alkaloid isoquinoline and a low-molecular-weight cationic peptide of the lantibiotic family hominin, which inhibits the development of bacterial biofilms of the clinical strain of Staphylococcus haemolyticus and its vancomycin-resistant isolates. It was found that combinations of these compounds have a synergistic effect that suppresses the formation of biofilms of both studied strains of staphylococci at reduced concentrations of these antibacterial compounds. |
| format | Article |
| id | doaj-art-ca685f747f3c4878ae30464a556d0112 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-08-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-ca685f747f3c4878ae30464a556d01122025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-08-01655-6111810.37489/0235-2990-2020-65-5-6-11-18724Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant StaphylococciL. I. Kononova0I. A. Pyankov1A. A. Smolyak2Yu. V. Shklyaev3V. P. Korobov4Institute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branch of the Russian Academy of SciencesPerm National Research Polytechnic UniversityInstitute of Technical Chemistry, Ural Branch of the Russian Academy of SciencesInstitute of Technical Chemistry, Ural Branch of the Russian Academy of SciencesInstitute of Ecology and Genetics of Microorganisms, Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences; Perm National Research Polytechnic UniversityThe growing threat of proliferation of biofilm-forming hospital strains of coagulase-negative staphylococci resistant to antibiotics determines the need for an urgent search for new effective antibacterial compounds, as well as the development of methods for the combined use of traditional and alternative antibiotics. The article presents the results of a study of the combined effect of the drug «SA» — a new synthetic derivative of the alkaloid isoquinoline and a low-molecular-weight cationic peptide of the lantibiotic family hominin, which inhibits the development of bacterial biofilms of the clinical strain of Staphylococcus haemolyticus and its vancomycin-resistant isolates. It was found that combinations of these compounds have a synergistic effect that suppresses the formation of biofilms of both studied strains of staphylococci at reduced concentrations of these antibacterial compounds.https://www.antibiotics-chemotherapy.ru/jour/article/view/734staphylococciadhesionbiofilmsdisinfectantsisoquinolinehomininminimal biofilm inhibitory concentrationsynergism |
| spellingShingle | L. I. Kononova I. A. Pyankov A. A. Smolyak Yu. V. Shklyaev V. P. Korobov Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant Staphylococci Антибиотики и Химиотерапия staphylococci adhesion biofilms disinfectants isoquinoline hominin minimal biofilm inhibitory concentration synergism |
| title | Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant Staphylococci |
| title_full | Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant Staphylococci |
| title_fullStr | Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant Staphylococci |
| title_full_unstemmed | Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant Staphylococci |
| title_short | Synergistic Effect of the Cationic Peptide Hominin and a New Disinfectant Based on Isoquinoline on Formation of Biofilms in Multidrug-Resistant Staphylococci |
| title_sort | synergistic effect of the cationic peptide hominin and a new disinfectant based on isoquinoline on formation of biofilms in multidrug resistant staphylococci |
| topic | staphylococci adhesion biofilms disinfectants isoquinoline hominin minimal biofilm inhibitory concentration synergism |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/734 |
| work_keys_str_mv | AT likononova synergisticeffectofthecationicpeptidehomininandanewdisinfectantbasedonisoquinolineonformationofbiofilmsinmultidrugresistantstaphylococci AT iapyankov synergisticeffectofthecationicpeptidehomininandanewdisinfectantbasedonisoquinolineonformationofbiofilmsinmultidrugresistantstaphylococci AT aasmolyak synergisticeffectofthecationicpeptidehomininandanewdisinfectantbasedonisoquinolineonformationofbiofilmsinmultidrugresistantstaphylococci AT yuvshklyaev synergisticeffectofthecationicpeptidehomininandanewdisinfectantbasedonisoquinolineonformationofbiofilmsinmultidrugresistantstaphylococci AT vpkorobov synergisticeffectofthecationicpeptidehomininandanewdisinfectantbasedonisoquinolineonformationofbiofilmsinmultidrugresistantstaphylococci |