Upcoming Therapeutic Modalities for the Treatment of Keloids: An Update
Introduction: Keloids are benign dermal tumors that generally form by local fibroblast proliferation and excessive collagen production following skin trauma. Several methods have been described for the treatment of keloid, often with suboptimal results and recurrences. Objective: To update liter...
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| Format: | Article |
| Language: | English |
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Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)
2019-03-01
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| Series: | Nepal Journal of Dermatology, Venereology & Leprology |
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| Online Access: | https://www.nepjol.info/index.php/NJDVL/article/view/23333 |
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| _version_ | 1849227462073909248 |
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| author | Uma Keyal Anil Kumar Bhatta |
| author_facet | Uma Keyal Anil Kumar Bhatta |
| author_sort | Uma Keyal |
| collection | DOAJ |
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Introduction: Keloids are benign dermal tumors that generally form by local fibroblast proliferation and excessive collagen production following skin trauma. Several methods have been described for the treatment of keloid, often with suboptimal results and recurrences.
Objective: To update literature that provides information regarding upcoming therapeutic modalities for the treatment of keloids, including lasers, radiofrequency (RF), photodynamic therapy (PDT), and ultraviolet A1 (UVA1) irradiation.
Materials and Methods : A systematic review of the literature was performed for the original articles related to the treatment of keloids. The search terms ‘keloids’ and ‘lasers’ or ‘radiofrequency’ or ‘PDT’ or ‘UVA1’ was entered into a search of the National Library of Medicine’s PubMed Database.
Result: The search returned a total of 188 sources, of which, 26 articles met our inclusion criteria.
Conclusion: Combination approach is superior than solo therapy in the treatment of keloid. However, it is highly desirable that new emerging therapies undergo large-scale studies with long-term follow-up before being recommended conclusively as alternative therapies for the treatment of keloid. Moreover, lack of randomized clinical trials (RCTs) needs to be taken into consideration urgently.
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| format | Article |
| id | doaj-art-ca64c609b9d84ec7ad065f287552a716 |
| institution | Kabale University |
| issn | 2091-0231 2091-167X |
| language | English |
| publishDate | 2019-03-01 |
| publisher | Society of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON) |
| record_format | Article |
| series | Nepal Journal of Dermatology, Venereology & Leprology |
| spelling | doaj-art-ca64c609b9d84ec7ad065f287552a7162025-08-23T10:04:30ZengSociety of Dermatologists, Venereologists and Leprologists of Nepal (SODVELON)Nepal Journal of Dermatology, Venereology & Leprology2091-02312091-167X2019-03-0117110.3126/njdvl.v17i1.23333Upcoming Therapeutic Modalities for the Treatment of Keloids: An UpdateUma Keyal0Anil Kumar Bhatta1DI skin Hospital, Maharajgung, KathmanduLet Me In Korean Aesthetic Hospital, Baneshwor, Kathmandu Introduction: Keloids are benign dermal tumors that generally form by local fibroblast proliferation and excessive collagen production following skin trauma. Several methods have been described for the treatment of keloid, often with suboptimal results and recurrences. Objective: To update literature that provides information regarding upcoming therapeutic modalities for the treatment of keloids, including lasers, radiofrequency (RF), photodynamic therapy (PDT), and ultraviolet A1 (UVA1) irradiation. Materials and Methods : A systematic review of the literature was performed for the original articles related to the treatment of keloids. The search terms ‘keloids’ and ‘lasers’ or ‘radiofrequency’ or ‘PDT’ or ‘UVA1’ was entered into a search of the National Library of Medicine’s PubMed Database. Result: The search returned a total of 188 sources, of which, 26 articles met our inclusion criteria. Conclusion: Combination approach is superior than solo therapy in the treatment of keloid. However, it is highly desirable that new emerging therapies undergo large-scale studies with long-term follow-up before being recommended conclusively as alternative therapies for the treatment of keloid. Moreover, lack of randomized clinical trials (RCTs) needs to be taken into consideration urgently. https://www.nepjol.info/index.php/NJDVL/article/view/23333CollagenFibroblastsKeloidPhotochemotherapyUltraviolet therapy |
| spellingShingle | Uma Keyal Anil Kumar Bhatta Upcoming Therapeutic Modalities for the Treatment of Keloids: An Update Nepal Journal of Dermatology, Venereology & Leprology Collagen Fibroblasts Keloid Photochemotherapy Ultraviolet therapy |
| title | Upcoming Therapeutic Modalities for the Treatment of Keloids: An Update |
| title_full | Upcoming Therapeutic Modalities for the Treatment of Keloids: An Update |
| title_fullStr | Upcoming Therapeutic Modalities for the Treatment of Keloids: An Update |
| title_full_unstemmed | Upcoming Therapeutic Modalities for the Treatment of Keloids: An Update |
| title_short | Upcoming Therapeutic Modalities for the Treatment of Keloids: An Update |
| title_sort | upcoming therapeutic modalities for the treatment of keloids an update |
| topic | Collagen Fibroblasts Keloid Photochemotherapy Ultraviolet therapy |
| url | https://www.nepjol.info/index.php/NJDVL/article/view/23333 |
| work_keys_str_mv | AT umakeyal upcomingtherapeuticmodalitiesforthetreatmentofkeloidsanupdate AT anilkumarbhatta upcomingtherapeuticmodalitiesforthetreatmentofkeloidsanupdate |