Insulin-like growth factor-binding protein-3 is induced by tamoxifen and fulvestrant and modulates fulvestrant response in breast cancer cells

Insulin-like growth factor-binding protein-3 is induced by tamoxifen and fulvestrant and modulates fulvestrant response in breast cancer cells

IntroductionInsulin-like growth factor binding protein-3 (IGFBP-3) exerts varying effects on estrogen receptor alpha (ERα)-positive and triple-negative breast cancer (TNBC) cells. In ERα-positive cells, IGFBP-3 is antiproliferative and proapoptotic. In contrast, IGFBP-3 stimulates proliferation in t...

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Bibliographic Details
Main Authors: Keenan L. Flynn, Yan Zheng, Janel Y. Sowers, Nefretiri J. T. Masangya, Kevin D. Houston
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Oncology
Subjects:
GPER1
Yap/Taz
fulvestrant
triple negative breast cancer
IGFBP-3
insulin like growth factor binding protein
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1452981/full
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