Antifouling Surface‐Attached Hydrogel Nanocoatings Redefined: Green Solvent‐Based, Degradable, and High‐Performance Protection Against Foulants
Abstract Antifouling coatings are vital to enhance the performance of medical devices, aiming to mitigate bodily reactions by shielding their surface. Despite significant advancements in antifouling coatings, like those based on zwitterionic monomers and hydroxyl‐functionalized (meth)acrylamides, li...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-06-01
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| Series: | Advanced Materials Interfaces |
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| Online Access: | https://doi.org/10.1002/admi.202500122 |
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| author | Jenny Englert Marc Palà Jonas Quandt Hannah Sieben Oliver Grottke Bernd Marx Gerard Lligadas Cesar Rodriguez‐Emmenegger |
| author_facet | Jenny Englert Marc Palà Jonas Quandt Hannah Sieben Oliver Grottke Bernd Marx Gerard Lligadas Cesar Rodriguez‐Emmenegger |
| author_sort | Jenny Englert |
| collection | DOAJ |
| description | Abstract Antifouling coatings are vital to enhance the performance of medical devices, aiming to mitigate bodily reactions by shielding their surface. Despite significant advancements in antifouling coatings, like those based on zwitterionic monomers and hydroxyl‐functionalized (meth)acrylamides, limitations like decreased antifouling properties after functionalization and complement system activation hinder their application in blood. Here, a novel class of ultrathin surface‐attached hydrogels is presented, consisting of hydrophilic non‐charged green solvent‐based monomers and preventing protein adsorption while offering on‐demand degradability. Unlike the best antifouling brushes, the coatings are easily applicable, unaffected by charges, and free of complement system‐activating groups. The hydrogels are formed using copolymers of N,N‐dimethyl lactamide acrylate (DMLA) and benzophenone acrylate (BPA). Moreover, 5,6‐benzo‐2‐methylene‐1,3‐dioxepane (BMDO) is incorporated to introduce hydrolyzable ester. The coating of state‐of‐the‐art devices is demonstrated with X‐ray photoelectron spectroscopy (XPS), analyze surface energy components, and confirm their antifouling properties with surface plasmon resonance (SPR). The coatings are non‐cytotoxic toward MRC‐5 fibroblasts, exhibit repellency against methicillin‐resistant Staphylococcus aureus (MRSA), and effectively prevent thrombus formation on devices in blood. This work establishes a versatile platform for next‐generation coatings in medical and industrial applications, matching the antifouling efficiency of the most advanced solutions and offering regeneration of substrates by erasing the coating. |
| format | Article |
| id | doaj-art-ca5e2126f60c47bc8c28882c6af25d4d |
| institution | OA Journals |
| issn | 2196-7350 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Materials Interfaces |
| spelling | doaj-art-ca5e2126f60c47bc8c28882c6af25d4d2025-08-20T02:38:18ZengWiley-VCHAdvanced Materials Interfaces2196-73502025-06-011212n/an/a10.1002/admi.202500122Antifouling Surface‐Attached Hydrogel Nanocoatings Redefined: Green Solvent‐Based, Degradable, and High‐Performance Protection Against FoulantsJenny Englert0Marc Palà1Jonas Quandt2Hannah Sieben3Oliver Grottke4Bernd Marx5Gerard Lligadas6Cesar Rodriguez‐Emmenegger7DWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 52074 Aachen GermanyUniversitat Rovira i Virgili Departament de Química Analítica i Química Orgànica Laboratory of Sustainable Polymers Tarragona 43007 SpainDWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 52074 Aachen GermanyDepartment of Anesthesiology RWTH Aachen University Hospital 52074 Aachen GermanyDepartment of Anesthesiology RWTH Aachen University Hospital 52074 Aachen GermanyVygon GmbH & Co. KG – Medizintechnik Prager Ring 100 52070 Aachen GermanyUniversitat Rovira i Virgili Departament de Química Analítica i Química Orgànica Laboratory of Sustainable Polymers Tarragona 43007 SpainDWI – Leibniz Institute for Interactive Materials Forckenbeckstraße 50 52074 Aachen GermanyAbstract Antifouling coatings are vital to enhance the performance of medical devices, aiming to mitigate bodily reactions by shielding their surface. Despite significant advancements in antifouling coatings, like those based on zwitterionic monomers and hydroxyl‐functionalized (meth)acrylamides, limitations like decreased antifouling properties after functionalization and complement system activation hinder their application in blood. Here, a novel class of ultrathin surface‐attached hydrogels is presented, consisting of hydrophilic non‐charged green solvent‐based monomers and preventing protein adsorption while offering on‐demand degradability. Unlike the best antifouling brushes, the coatings are easily applicable, unaffected by charges, and free of complement system‐activating groups. The hydrogels are formed using copolymers of N,N‐dimethyl lactamide acrylate (DMLA) and benzophenone acrylate (BPA). Moreover, 5,6‐benzo‐2‐methylene‐1,3‐dioxepane (BMDO) is incorporated to introduce hydrolyzable ester. The coating of state‐of‐the‐art devices is demonstrated with X‐ray photoelectron spectroscopy (XPS), analyze surface energy components, and confirm their antifouling properties with surface plasmon resonance (SPR). The coatings are non‐cytotoxic toward MRC‐5 fibroblasts, exhibit repellency against methicillin‐resistant Staphylococcus aureus (MRSA), and effectively prevent thrombus formation on devices in blood. This work establishes a versatile platform for next‐generation coatings in medical and industrial applications, matching the antifouling efficiency of the most advanced solutions and offering regeneration of substrates by erasing the coating.https://doi.org/10.1002/admi.202500122antifoulingbiocompatibilitycoatingdegradabilitygreen solventhydrogel |
| spellingShingle | Jenny Englert Marc Palà Jonas Quandt Hannah Sieben Oliver Grottke Bernd Marx Gerard Lligadas Cesar Rodriguez‐Emmenegger Antifouling Surface‐Attached Hydrogel Nanocoatings Redefined: Green Solvent‐Based, Degradable, and High‐Performance Protection Against Foulants Advanced Materials Interfaces antifouling biocompatibility coating degradability green solvent hydrogel |
| title | Antifouling Surface‐Attached Hydrogel Nanocoatings Redefined: Green Solvent‐Based, Degradable, and High‐Performance Protection Against Foulants |
| title_full | Antifouling Surface‐Attached Hydrogel Nanocoatings Redefined: Green Solvent‐Based, Degradable, and High‐Performance Protection Against Foulants |
| title_fullStr | Antifouling Surface‐Attached Hydrogel Nanocoatings Redefined: Green Solvent‐Based, Degradable, and High‐Performance Protection Against Foulants |
| title_full_unstemmed | Antifouling Surface‐Attached Hydrogel Nanocoatings Redefined: Green Solvent‐Based, Degradable, and High‐Performance Protection Against Foulants |
| title_short | Antifouling Surface‐Attached Hydrogel Nanocoatings Redefined: Green Solvent‐Based, Degradable, and High‐Performance Protection Against Foulants |
| title_sort | antifouling surface attached hydrogel nanocoatings redefined green solvent based degradable and high performance protection against foulants |
| topic | antifouling biocompatibility coating degradability green solvent hydrogel |
| url | https://doi.org/10.1002/admi.202500122 |
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