Spatial dynamics of spontaneous activity in the developing and adult cortices
Even in the absence of external stimuli, the brain remains remarkably active, with neurons continuously firing and communicating with each other. It is not merely random firing of individual neurons but rather orchestrated patterns of activity that propagate throughout the intricate network. Over tw...
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Elsevier
2025-03-01
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| Series: | Neuroscience Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0168010224001524 |
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| author | Tomonari Murakami |
| author_facet | Tomonari Murakami |
| author_sort | Tomonari Murakami |
| collection | DOAJ |
| description | Even in the absence of external stimuli, the brain remains remarkably active, with neurons continuously firing and communicating with each other. It is not merely random firing of individual neurons but rather orchestrated patterns of activity that propagate throughout the intricate network. Over two decades, advancements in neuroscience observation tools for hemodynamics, membrane potential, and neural calcium signals, have allowed researchers to analyze the dynamics of spontaneous activity across different spatial scales, from individual neurons to macroscale brain networks. One of the remarkable findings from these studies is that the spatial patterns of spontaneous activity in the developing brain are vastly different from those in the mature adult brain. Spatial patterns of spontaneous activity during development are essential for connection refinement between brain regions, whereas the functional role in the adult brain is still controversial. In this paper, I review the differences in spatial dynamics of spontaneous activity between developing and adult cortices. Then, I delve into the cellular mechanisms underlying spontaneous activity, especially its generation and propagation manner, to contribute to a deeper understanding of brain function and its development. |
| format | Article |
| id | doaj-art-ca50348c1f184366a6bcabc8380ed76c |
| institution | OA Journals |
| issn | 0168-0102 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neuroscience Research |
| spelling | doaj-art-ca50348c1f184366a6bcabc8380ed76c2025-08-20T02:02:24ZengElsevierNeuroscience Research0168-01022025-03-0121211010.1016/j.neures.2024.12.002Spatial dynamics of spontaneous activity in the developing and adult corticesTomonari Murakami0Department of Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Institute for AI and Beyond, The University of Tokyo, Tokyo, Japan; Corresponding author at: Department of Physiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.Even in the absence of external stimuli, the brain remains remarkably active, with neurons continuously firing and communicating with each other. It is not merely random firing of individual neurons but rather orchestrated patterns of activity that propagate throughout the intricate network. Over two decades, advancements in neuroscience observation tools for hemodynamics, membrane potential, and neural calcium signals, have allowed researchers to analyze the dynamics of spontaneous activity across different spatial scales, from individual neurons to macroscale brain networks. One of the remarkable findings from these studies is that the spatial patterns of spontaneous activity in the developing brain are vastly different from those in the mature adult brain. Spatial patterns of spontaneous activity during development are essential for connection refinement between brain regions, whereas the functional role in the adult brain is still controversial. In this paper, I review the differences in spatial dynamics of spontaneous activity between developing and adult cortices. Then, I delve into the cellular mechanisms underlying spontaneous activity, especially its generation and propagation manner, to contribute to a deeper understanding of brain function and its development.http://www.sciencedirect.com/science/article/pii/S0168010224001524Spontaneous activitySpatial patternActivity propagationWide-field Ca2 + imagingMature cortexDevelopment |
| spellingShingle | Tomonari Murakami Spatial dynamics of spontaneous activity in the developing and adult cortices Neuroscience Research Spontaneous activity Spatial pattern Activity propagation Wide-field Ca2 + imaging Mature cortex Development |
| title | Spatial dynamics of spontaneous activity in the developing and adult cortices |
| title_full | Spatial dynamics of spontaneous activity in the developing and adult cortices |
| title_fullStr | Spatial dynamics of spontaneous activity in the developing and adult cortices |
| title_full_unstemmed | Spatial dynamics of spontaneous activity in the developing and adult cortices |
| title_short | Spatial dynamics of spontaneous activity in the developing and adult cortices |
| title_sort | spatial dynamics of spontaneous activity in the developing and adult cortices |
| topic | Spontaneous activity Spatial pattern Activity propagation Wide-field Ca2 + imaging Mature cortex Development |
| url | http://www.sciencedirect.com/science/article/pii/S0168010224001524 |
| work_keys_str_mv | AT tomonarimurakami spatialdynamicsofspontaneousactivityinthedevelopingandadultcortices |