Epicatechin attenuates the stemness of liver cancer stem cells and tumorigenesis through DNA methylation-mediated inactivation of GINS1/HRAS

Epicatechin attenuates the stemness of liver cancer stem cells and tumorigenesis through DNA methylation-mediated inactivation of GINS1/HRAS

Abstract Background The limited therapeutic options for hepatocellular carcinoma (HCC) are primarily attributed to the presence of liver cancer stem cells (LCSCs). Epicatechin (EC) is known to exert therapeutic effects on cancer. Go-ichi-ni-san complex subunit 1 (GINS1) is an oncogene associated wit...

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Bibliographic Details
Main Authors: Xingbao Fang, Yan Cai, Xiongbing Peng, Zhaojun Li, Meifang Huang, Yuehong Li, Peiwan Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Hepatocellular carcinoma
Cancer stem cell
Epicatechin
DNA methylation
GINS1
HRAS
Online Access:https://doi.org/10.1186/s12967-025-06790-y
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