Beyond Amputation: Functional Restoration after Upper-Extremity Limb Loss

Several factors have contributed to poor quality of life outcomes for upper-extremity amputees. In recent decades, the advancements in both surgical procedures and prosthetics have been aimed at both improving the function and quality of life of amputees. Targeted muscle reinnervation, regenerative...

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Main Authors: Jonathan T. Bricker, MD, Kazimir R. Bagdady, BS, Lindsay E. Janes, MD, Jason M. Souza, MD, Gregory A. Dumanian, MD, Jason H. Ko, MD, MBA
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Journal of Hand Surgery Global Online
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Online Access:http://www.sciencedirect.com/science/article/pii/S258951412500009X
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author Jonathan T. Bricker, MD
Kazimir R. Bagdady, BS
Lindsay E. Janes, MD
Jason M. Souza, MD
Gregory A. Dumanian, MD
Jason H. Ko, MD, MBA
author_facet Jonathan T. Bricker, MD
Kazimir R. Bagdady, BS
Lindsay E. Janes, MD
Jason M. Souza, MD
Gregory A. Dumanian, MD
Jason H. Ko, MD, MBA
author_sort Jonathan T. Bricker, MD
collection DOAJ
description Several factors have contributed to poor quality of life outcomes for upper-extremity amputees. In recent decades, the advancements in both surgical procedures and prosthetics have been aimed at both improving the function and quality of life of amputees. Targeted muscle reinnervation, regenerative peripheral nerve interfaces, agonist–antagonist myoneural interfaces, free tissue transfers, and limb transplantation are chief among the surgical options available for improved sensorimotor function in residual and prosthetic limbs. New technologies such as cuff electrodes, intraneural filaments, and various osseointegrated prosthesis systems are used either alone or in concert with these operative techniques. Procedural and technological advancements will continue to push the limits of functional restoration after upper-extremity limb loss.
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issn 2589-5141
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publishDate 2025-03-01
publisher Elsevier
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series Journal of Hand Surgery Global Online
spelling doaj-art-ca4a3f0fe55d46859631a899a3cca5402025-08-20T02:52:23ZengElsevierJournal of Hand Surgery Global Online2589-51412025-03-017236837510.1016/j.jhsg.2025.01.008Beyond Amputation: Functional Restoration after Upper-Extremity Limb LossJonathan T. Bricker, MD0Kazimir R. Bagdady, BS1Lindsay E. Janes, MD2Jason M. Souza, MD3Gregory A. Dumanian, MD4Jason H. Ko, MD, MBA5Division of Plastic & Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, ILDivision of Plastic & Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, ILDivision of Plastic & Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, ILDepartments of Plastic and Reconstructive Surgery and Orthopedic Surgery, The Ohio State University Wexner Medical Center, Columbus, OHDivision of Plastic & Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, ILDivision of Plastic & Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL; Corresponding author: Jason H. Ko, MD, MBA, Division of Plastic & Reconstructive Surgery, Department of Orthopedic Surgery, Northwestern University Feinberg School of Medicine, 259 E Erie St., Floor 20, Suite 2060, Chicago, IL 60611.Several factors have contributed to poor quality of life outcomes for upper-extremity amputees. In recent decades, the advancements in both surgical procedures and prosthetics have been aimed at both improving the function and quality of life of amputees. Targeted muscle reinnervation, regenerative peripheral nerve interfaces, agonist–antagonist myoneural interfaces, free tissue transfers, and limb transplantation are chief among the surgical options available for improved sensorimotor function in residual and prosthetic limbs. New technologies such as cuff electrodes, intraneural filaments, and various osseointegrated prosthesis systems are used either alone or in concert with these operative techniques. Procedural and technological advancements will continue to push the limits of functional restoration after upper-extremity limb loss.http://www.sciencedirect.com/science/article/pii/S258951412500009XFree tissue transferOsseointegrationRegenerative peripheral nerve interfacesTargeted muscle reinnervationUpper-extremity amputation
spellingShingle Jonathan T. Bricker, MD
Kazimir R. Bagdady, BS
Lindsay E. Janes, MD
Jason M. Souza, MD
Gregory A. Dumanian, MD
Jason H. Ko, MD, MBA
Beyond Amputation: Functional Restoration after Upper-Extremity Limb Loss
Journal of Hand Surgery Global Online
Free tissue transfer
Osseointegration
Regenerative peripheral nerve interfaces
Targeted muscle reinnervation
Upper-extremity amputation
title Beyond Amputation: Functional Restoration after Upper-Extremity Limb Loss
title_full Beyond Amputation: Functional Restoration after Upper-Extremity Limb Loss
title_fullStr Beyond Amputation: Functional Restoration after Upper-Extremity Limb Loss
title_full_unstemmed Beyond Amputation: Functional Restoration after Upper-Extremity Limb Loss
title_short Beyond Amputation: Functional Restoration after Upper-Extremity Limb Loss
title_sort beyond amputation functional restoration after upper extremity limb loss
topic Free tissue transfer
Osseointegration
Regenerative peripheral nerve interfaces
Targeted muscle reinnervation
Upper-extremity amputation
url http://www.sciencedirect.com/science/article/pii/S258951412500009X
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