Amino acid neurotransmitters in sarcopenia and healthy aging
Sarcopenia is the age-related degeneration of skeletal muscle. Healthy skeletal muscle secretes metabolites and macromolecules that are systemically important for the immune system (e.g. myokines) and the central nervous system (e.g. BDNF). Exercise interventions to stimulate skeletal muscle are the...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025002497 |
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| author | Steffi M. Jonk James R. Tribble Peter Swoboda Pete A. Williams |
| author_facet | Steffi M. Jonk James R. Tribble Peter Swoboda Pete A. Williams |
| author_sort | Steffi M. Jonk |
| collection | DOAJ |
| description | Sarcopenia is the age-related degeneration of skeletal muscle. Healthy skeletal muscle secretes metabolites and macromolecules that are systemically important for the immune system (e.g. myokines) and the central nervous system (e.g. BDNF). Exercise interventions to stimulate skeletal muscle are therapeutic for sarcopenia and limit risk and/or provide neuroprotection in neurodegenerative disease models. Metabolic analysis of aged skeletal muscle has identified altered skeletal muscle metabolomes at an old age. Many of the molecules identified are amino acids that also act as neurotransmitters. In this review, we summarize how 13 amino acids act as neurotransmitters or as precursor to neurotransmitters, and how these are involved in the skeletal muscle secretome, sarcopenia, and (healthy) aging. |
| format | Article |
| id | doaj-art-ca4971b517c84076a810ed0daa16766f |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-ca4971b517c84076a810ed0daa16766f2025-08-20T03:42:14ZengElsevierBrain Research Bulletin1873-27472025-09-0122911143710.1016/j.brainresbull.2025.111437Amino acid neurotransmitters in sarcopenia and healthy agingSteffi M. Jonk0James R. Tribble1Peter Swoboda2Pete A. Williams3Department of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, SwedenDepartment of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, SwedenDepartment of Medicine Huddinge (MedH), Biosciences and Nutrition Unit, NEO, Karolinska Institutet, Huddinge, SwedenDepartment of Clinical Neuroscience, Division of Eye and Vision, St. Erik Eye Hospital, Karolinska Institutet, Stockholm, Sweden; Corresponding author.Sarcopenia is the age-related degeneration of skeletal muscle. Healthy skeletal muscle secretes metabolites and macromolecules that are systemically important for the immune system (e.g. myokines) and the central nervous system (e.g. BDNF). Exercise interventions to stimulate skeletal muscle are therapeutic for sarcopenia and limit risk and/or provide neuroprotection in neurodegenerative disease models. Metabolic analysis of aged skeletal muscle has identified altered skeletal muscle metabolomes at an old age. Many of the molecules identified are amino acids that also act as neurotransmitters. In this review, we summarize how 13 amino acids act as neurotransmitters or as precursor to neurotransmitters, and how these are involved in the skeletal muscle secretome, sarcopenia, and (healthy) aging.http://www.sciencedirect.com/science/article/pii/S0361923025002497SarcopeniaMuscleMetabolomicsAmino acidsNeurotransmitters |
| spellingShingle | Steffi M. Jonk James R. Tribble Peter Swoboda Pete A. Williams Amino acid neurotransmitters in sarcopenia and healthy aging Brain Research Bulletin Sarcopenia Muscle Metabolomics Amino acids Neurotransmitters |
| title | Amino acid neurotransmitters in sarcopenia and healthy aging |
| title_full | Amino acid neurotransmitters in sarcopenia and healthy aging |
| title_fullStr | Amino acid neurotransmitters in sarcopenia and healthy aging |
| title_full_unstemmed | Amino acid neurotransmitters in sarcopenia and healthy aging |
| title_short | Amino acid neurotransmitters in sarcopenia and healthy aging |
| title_sort | amino acid neurotransmitters in sarcopenia and healthy aging |
| topic | Sarcopenia Muscle Metabolomics Amino acids Neurotransmitters |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025002497 |
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