The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of Preeclampsia
Preeclampsia is a hypertension condition of human pregnancy that poses a significant risk to pregnant women and their fetus. It complicates about 2–8% of human pregnancies worldwide and displays multifactorial pathogenesis, including increased placental oxidative stress because of disturbed utero-pl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/14/5/529 |
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| author | Alexandra Barbouti Dimitrios N. Varvarousis Panagiotis Kanavaros |
| author_facet | Alexandra Barbouti Dimitrios N. Varvarousis Panagiotis Kanavaros |
| author_sort | Alexandra Barbouti |
| collection | DOAJ |
| description | Preeclampsia is a hypertension condition of human pregnancy that poses a significant risk to pregnant women and their fetus. It complicates about 2–8% of human pregnancies worldwide and displays multifactorial pathogenesis, including increased placental oxidative stress because of disturbed utero-placental blood flow. Recent evidence suggests that increased oxidative stress promotes acceleration of the placental senescence which is implicated in the pathogenesis of preeclampsia. This review focuses on the mechanisms that lead to oxidative stress in preeclamptic patients and examines the role of oxidative stress-induced placental senescence in the pathogenesis of the disease. |
| format | Article |
| id | doaj-art-ca48a18ab22e475fa9de2e7c1aa9d06d |
| institution | DOAJ |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-ca48a18ab22e475fa9de2e7c1aa9d06d2025-08-20T03:14:29ZengMDPI AGAntioxidants2076-39212025-04-0114552910.3390/antiox14050529The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of PreeclampsiaAlexandra Barbouti0Dimitrios N. Varvarousis1Panagiotis Kanavaros2Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceDepartment of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreecePreeclampsia is a hypertension condition of human pregnancy that poses a significant risk to pregnant women and their fetus. It complicates about 2–8% of human pregnancies worldwide and displays multifactorial pathogenesis, including increased placental oxidative stress because of disturbed utero-placental blood flow. Recent evidence suggests that increased oxidative stress promotes acceleration of the placental senescence which is implicated in the pathogenesis of preeclampsia. This review focuses on the mechanisms that lead to oxidative stress in preeclamptic patients and examines the role of oxidative stress-induced placental senescence in the pathogenesis of the disease.https://www.mdpi.com/2076-3921/14/5/529oxidative stresscellular senescencepreeclampsiaplacentaischemia and reperfusion |
| spellingShingle | Alexandra Barbouti Dimitrios N. Varvarousis Panagiotis Kanavaros The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of Preeclampsia Antioxidants oxidative stress cellular senescence preeclampsia placenta ischemia and reperfusion |
| title | The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of Preeclampsia |
| title_full | The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of Preeclampsia |
| title_fullStr | The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of Preeclampsia |
| title_full_unstemmed | The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of Preeclampsia |
| title_short | The Role of Oxidative Stress-Induced Senescence in the Pathogenesis of Preeclampsia |
| title_sort | role of oxidative stress induced senescence in the pathogenesis of preeclampsia |
| topic | oxidative stress cellular senescence preeclampsia placenta ischemia and reperfusion |
| url | https://www.mdpi.com/2076-3921/14/5/529 |
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