New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease
Abstract Parkinson’s disease (PD), a prevalent neurodegenerative disorder, is linked to genetics and environment, but its mechanisms remain unclear. Emerging evidence connects purinergic signaling-particularly ATP-sensitive P2X7 receptor (P2X7R)-to PD. P2X7R expression is elevated in PD patients, an...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-05-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00980-7 |
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| _version_ | 1849311481550602240 |
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| author | Shizhuang Wei Xiaoyu Song Yakui Mou Ting Yang Yao Wang Hanrui Wang Chao Ren Xicheng Song |
| author_facet | Shizhuang Wei Xiaoyu Song Yakui Mou Ting Yang Yao Wang Hanrui Wang Chao Ren Xicheng Song |
| author_sort | Shizhuang Wei |
| collection | DOAJ |
| description | Abstract Parkinson’s disease (PD), a prevalent neurodegenerative disorder, is linked to genetics and environment, but its mechanisms remain unclear. Emerging evidence connects purinergic signaling-particularly ATP-sensitive P2X7 receptor (P2X7R)-to PD. P2X7R expression is elevated in PD patients, and its antagonist BBG mitigates 6-OHDA-induced dopaminergic neuron death. This review discusses P2X7R’s structure, neural functions, PD-related mechanisms, and therapeutic potential as a targert. |
| format | Article |
| id | doaj-art-ca4280b524c44dedb0f3f16616e4baac |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-ca4280b524c44dedb0f3f16616e4baac2025-08-20T03:53:22ZengNature Portfolionpj Parkinson's Disease2373-80572025-05-0111111010.1038/s41531-025-00980-7New insights into pathogenisis and therapies of P2X7R in Parkinson’s diseaseShizhuang Wei0Xiaoyu Song1Yakui Mou2Ting Yang3Yao Wang4Hanrui Wang5Chao Ren6Xicheng Song7Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao UniversityDepartment of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao UniversityAbstract Parkinson’s disease (PD), a prevalent neurodegenerative disorder, is linked to genetics and environment, but its mechanisms remain unclear. Emerging evidence connects purinergic signaling-particularly ATP-sensitive P2X7 receptor (P2X7R)-to PD. P2X7R expression is elevated in PD patients, and its antagonist BBG mitigates 6-OHDA-induced dopaminergic neuron death. This review discusses P2X7R’s structure, neural functions, PD-related mechanisms, and therapeutic potential as a targert.https://doi.org/10.1038/s41531-025-00980-7 |
| spellingShingle | Shizhuang Wei Xiaoyu Song Yakui Mou Ting Yang Yao Wang Hanrui Wang Chao Ren Xicheng Song New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease npj Parkinson's Disease |
| title | New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease |
| title_full | New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease |
| title_fullStr | New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease |
| title_full_unstemmed | New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease |
| title_short | New insights into pathogenisis and therapies of P2X7R in Parkinson’s disease |
| title_sort | new insights into pathogenisis and therapies of p2x7r in parkinson s disease |
| url | https://doi.org/10.1038/s41531-025-00980-7 |
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