An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis
Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by cartilage degeneration, disrupted subchondral bone remodeling, and synovitis, seriously affecting the quality of life of patients with chronic pain and functional disabilities. Current treatments for TMJOA are...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/6619527 |
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| author | Yifan Zhao Liang Xie |
| author_facet | Yifan Zhao Liang Xie |
| author_sort | Yifan Zhao |
| collection | DOAJ |
| description | Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by cartilage degeneration, disrupted subchondral bone remodeling, and synovitis, seriously affecting the quality of life of patients with chronic pain and functional disabilities. Current treatments for TMJOA are mainly symptomatic therapies without reliable long-term efficacy, due to the limited self-renewal capability of the condyle and the poorly elucidated pathogenesis of TMJOA. Recently, there has been increased interest in cellular therapies for osteoarthritis and TMJ regeneration. Mesenchymal stem cells (MSCs), self-renewing and multipotent progenitor cells, play a promising role in TMJOA treatment. Derived from a variety of tissues, MSCs exert therapeutic effects through diverse mechanisms, including chondrogenic differentiation; fibrocartilage regeneration; and trophic, immunomodulatory, and anti-inflammatory effects. Here, we provide an overview of the therapeutic roles of various tissue-specific MSCs in osteoarthritic TMJ or TMJ regenerative tissue engineering, with an additional focus on joint-resident stem cells and other cellular therapies, such as exosomes and adipose-derived stromal vascular fraction (SVF). Additionally, we summarized the updated pathogenesis of TMJOA to provide a better understanding of the pathological mechanisms of cellular therapies. Although limitations exist, MSC-centered therapies still provide novel, innovative approaches for TMJOA treatment. |
| format | Article |
| id | doaj-art-ca426c38fd974dbf8af03be3ddb40302 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-ca426c38fd974dbf8af03be3ddb403022025-08-20T02:19:37ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/66195276619527An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint OsteoarthritisYifan Zhao0Liang Xie1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaTemporomandibular joint osteoarthritis (TMJOA) is a degenerative disease characterized by cartilage degeneration, disrupted subchondral bone remodeling, and synovitis, seriously affecting the quality of life of patients with chronic pain and functional disabilities. Current treatments for TMJOA are mainly symptomatic therapies without reliable long-term efficacy, due to the limited self-renewal capability of the condyle and the poorly elucidated pathogenesis of TMJOA. Recently, there has been increased interest in cellular therapies for osteoarthritis and TMJ regeneration. Mesenchymal stem cells (MSCs), self-renewing and multipotent progenitor cells, play a promising role in TMJOA treatment. Derived from a variety of tissues, MSCs exert therapeutic effects through diverse mechanisms, including chondrogenic differentiation; fibrocartilage regeneration; and trophic, immunomodulatory, and anti-inflammatory effects. Here, we provide an overview of the therapeutic roles of various tissue-specific MSCs in osteoarthritic TMJ or TMJ regenerative tissue engineering, with an additional focus on joint-resident stem cells and other cellular therapies, such as exosomes and adipose-derived stromal vascular fraction (SVF). Additionally, we summarized the updated pathogenesis of TMJOA to provide a better understanding of the pathological mechanisms of cellular therapies. Although limitations exist, MSC-centered therapies still provide novel, innovative approaches for TMJOA treatment.http://dx.doi.org/10.1155/2021/6619527 |
| spellingShingle | Yifan Zhao Liang Xie An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis Stem Cells International |
| title | An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis |
| title_full | An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis |
| title_fullStr | An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis |
| title_full_unstemmed | An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis |
| title_short | An Update on Mesenchymal Stem Cell-Centered Therapies in Temporomandibular Joint Osteoarthritis |
| title_sort | update on mesenchymal stem cell centered therapies in temporomandibular joint osteoarthritis |
| url | http://dx.doi.org/10.1155/2021/6619527 |
| work_keys_str_mv | AT yifanzhao anupdateonmesenchymalstemcellcenteredtherapiesintemporomandibularjointosteoarthritis AT liangxie anupdateonmesenchymalstemcellcenteredtherapiesintemporomandibularjointosteoarthritis AT yifanzhao updateonmesenchymalstemcellcenteredtherapiesintemporomandibularjointosteoarthritis AT liangxie updateonmesenchymalstemcellcenteredtherapiesintemporomandibularjointosteoarthritis |