Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA)
Abstract Myocardial infarction with nonobstructive coronary arteries (MINOCA) constitutes 3–15% of all acute myocardial infarctions. Women are more frequently diagnosed with MINOCA, although the influence of sex on long-term outcomes is still unclear. In this study we aimed to compare sex-based diff...
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| Format: | Article |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-87121-5 |
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| author | Marek Milewski Aneta Desperak Maciej Koźlik Marta Bujak Marek Gierlotka Krzysztof Milewski Krystian Wita Zbigniew Kalarus Joanna Fluder-Włodarczyk Pawel E. Buszman Jacek Piegza Mamas A. Mamas Wojciech Wojakowski Pawel Gasior |
| author_facet | Marek Milewski Aneta Desperak Maciej Koźlik Marta Bujak Marek Gierlotka Krzysztof Milewski Krystian Wita Zbigniew Kalarus Joanna Fluder-Włodarczyk Pawel E. Buszman Jacek Piegza Mamas A. Mamas Wojciech Wojakowski Pawel Gasior |
| author_sort | Marek Milewski |
| collection | DOAJ |
| description | Abstract Myocardial infarction with nonobstructive coronary arteries (MINOCA) constitutes 3–15% of all acute myocardial infarctions. Women are more frequently diagnosed with MINOCA, although the influence of sex on long-term outcomes is still unclear. In this study we aimed to compare sex-based differences in baseline characteristics and clinical outcomes in patients with suspected MINOCA. We have retrospectively analyzed 6063 patients diagnosed with MINOCA (3220 females and 2843 male patients) from combined 3 large polish registries (PL-ACS, SILCARD and AMI-PL). Male patients were significantly younger (63 (55–74) vs. 71 (61–79) years, p < 0.05) and less frequently diabetic (20.1% vs. 24.1%, p < 0.05). Mortality was significantly higher in male population (11.8% vs. 10.2%, p < 0.05 at 1 year and 17.6% vs. 15.0%, p < 0.05 at 3 years). Male sex was an independent predictor of both mortality (HR = 1.29; CI 1.11–1.51; p < 0.05) and myocardial infarction (HR = 1.39; CI 1.1–1.75, p < 0.05) at 3 years follow-up. All-cause readmission rates were similar in male and female patients both at 1 year (46.0% vs. 44.4, p = 0.2) and 3 years follow-up (56.4% vs. 56.5%, p = 0.93). However, cardiovascular readmissions were more prevalent in male patients at both timepoints (33.9% vs. 29.10%, p < 0.05 at 1 year, and 41.0% vs. 37.6%, p < 0.05 at 3 years). This large-scale registry-based analysis demonstrated higher 3 years rates of adverse events, including death and MI among male patients with suspected MINOCA. |
| format | Article |
| id | doaj-art-ca4242096d8641aba3659ddf5141ca86 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-ca4242096d8641aba3659ddf5141ca862025-01-26T12:24:47ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-87121-5Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA)Marek Milewski0Aneta Desperak1Maciej Koźlik2Marta Bujak3Marek Gierlotka4Krzysztof Milewski5Krystian Wita6Zbigniew Kalarus7Joanna Fluder-Włodarczyk8Pawel E. Buszman9Jacek Piegza10Mamas A. Mamas11Wojciech Wojakowski12Pawel Gasior13Division of Cardiology and Structural Heart Diseases, Medical University of SilesiaDepartment of Cardiology, School of Medicine, Division of Dentistry in Zabrze, Silesian Center for Heart Diseases, Medical University of SilesiaDivision of Cardiology and Structural Heart Diseases, Medical University of SilesiaDivision of Cardiology and Structural Heart Diseases, Medical University of SilesiaDepartment of Cardiology, Institute of Medical Sciences, University Hospital, University of OpoleCentre for Cardiovascular Research and Development, American Heart of PolandFirst Department of Cardiology, School of Medicine in Katowice, Medical University of SilesiaDepartment of Cardiology, Congenital Heart Diseases and Electrotherapy, Silesian Center for Heart Diseases, Medical University of SilesiaDivision of Cardiology and Structural Heart Diseases, Medical University of SilesiaDepartment of Epidemiology and Statistics, Medical University of SilesiaDepartment of Cardiology, School of Medicine, Division of Dentistry in Zabrze, Silesian Center for Heart Diseases, Medical University of SilesiaKeele Cardiovascular Research Group, Keele UniversityDivision of Cardiology and Structural Heart Diseases, Medical University of SilesiaDivision of Cardiology and Structural Heart Diseases, Medical University of SilesiaAbstract Myocardial infarction with nonobstructive coronary arteries (MINOCA) constitutes 3–15% of all acute myocardial infarctions. Women are more frequently diagnosed with MINOCA, although the influence of sex on long-term outcomes is still unclear. In this study we aimed to compare sex-based differences in baseline characteristics and clinical outcomes in patients with suspected MINOCA. We have retrospectively analyzed 6063 patients diagnosed with MINOCA (3220 females and 2843 male patients) from combined 3 large polish registries (PL-ACS, SILCARD and AMI-PL). Male patients were significantly younger (63 (55–74) vs. 71 (61–79) years, p < 0.05) and less frequently diabetic (20.1% vs. 24.1%, p < 0.05). Mortality was significantly higher in male population (11.8% vs. 10.2%, p < 0.05 at 1 year and 17.6% vs. 15.0%, p < 0.05 at 3 years). Male sex was an independent predictor of both mortality (HR = 1.29; CI 1.11–1.51; p < 0.05) and myocardial infarction (HR = 1.39; CI 1.1–1.75, p < 0.05) at 3 years follow-up. All-cause readmission rates were similar in male and female patients both at 1 year (46.0% vs. 44.4, p = 0.2) and 3 years follow-up (56.4% vs. 56.5%, p = 0.93). However, cardiovascular readmissions were more prevalent in male patients at both timepoints (33.9% vs. 29.10%, p < 0.05 at 1 year, and 41.0% vs. 37.6%, p < 0.05 at 3 years). This large-scale registry-based analysis demonstrated higher 3 years rates of adverse events, including death and MI among male patients with suspected MINOCA.https://doi.org/10.1038/s41598-025-87121-5 |
| spellingShingle | Marek Milewski Aneta Desperak Maciej Koźlik Marta Bujak Marek Gierlotka Krzysztof Milewski Krystian Wita Zbigniew Kalarus Joanna Fluder-Włodarczyk Pawel E. Buszman Jacek Piegza Mamas A. Mamas Wojciech Wojakowski Pawel Gasior Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA) Scientific Reports |
| title | Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA) |
| title_full | Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA) |
| title_fullStr | Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA) |
| title_full_unstemmed | Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA) |
| title_short | Sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries (MINOCA) |
| title_sort | sex differences in patients with working diagnosis of myocardial infarction with nonobstructive coronary arteries minoca |
| url | https://doi.org/10.1038/s41598-025-87121-5 |
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