Indoximod Attenuates Inflammatory Responses in Acetic Acid-Induced Acute Colitis by Modulating Toll-like Receptor 4 (TLR4) Signaling and Proinflammatory Cytokines in Rats

Indoximod Attenuates Inflammatory Responses in Acetic Acid-Induced Acute Colitis by Modulating Toll-like Receptor 4 (TLR4) Signaling and Proinflammatory Cytokines in Rats

<i>Background and Objectives:</i> Acute ulcerative colitis is characterized by excessive mucosal inflammation and epithelial disruption, often driven by dysregulated cytokine and immune signaling. Indoximod (1-methyl-DL-tryptophan), although not a direct enzymatic inhibitor, modulates th...

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Bibliographic Details
Main Authors: Gulcin Ercan, Hatice Aygun, Ahmet Akbaş, Osman Sezer Çınaroğlu, Oytun Erbas
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Medicina
Subjects:
Indoximod
TLR4
TNF-α
pentraxin-3
acetic acid-induced colitis
PAF
Online Access:https://www.mdpi.com/1648-9144/61/6/1033
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