Chlamydial bacteriophage: No Role in Acute Coronary Events?
BACKGROUND: A relationship between Chlamydia pneumoniae infection and acute coronary syndromes has not been consistently found in published studies. It has been hypothesized that a bacteriophage-infected subset of C pneumoniae may be uniquely equipped to promote atherosclerosis and acute coronary sy...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2005-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2005/173147 |
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| _version_ | 1832567404323930112 |
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| author | David M Patrick Karuna Karunakaran Adrian R Levy Kenneth Gin Valencia Remple Mei Chong Heather Abbey Laura Tarry Caixia Shen Robert C Brunham |
| author_facet | David M Patrick Karuna Karunakaran Adrian R Levy Kenneth Gin Valencia Remple Mei Chong Heather Abbey Laura Tarry Caixia Shen Robert C Brunham |
| author_sort | David M Patrick |
| collection | DOAJ |
| description | BACKGROUND: A relationship between Chlamydia pneumoniae infection and acute coronary syndromes has not been consistently found in published studies. It has been hypothesized that a bacteriophage-infected subset of C pneumoniae may be uniquely equipped to promote atherosclerosis and acute coronary syndromes through the expression of phage genes. METHODS: The authors performed a pilot case-control study of acute coronary events. Case and control subjects were characterized demographically and according to recognized coronary risk factors. These subjects also provided serum for the detection of antibody to the elementary bodies of C pneumoniae and antibody to the Vp1 protein coded by the phage. Bivariate and multivariate comparisons were performed using statistics appropriate for paired analyses. RESULTS: Antibodies to C pneumoniae, Vp1 protein or both were not associated with acute coronary events by bivariate or multivariate analysis. As expected, case subjects were significantly more likely to have hypertension, hypercholesterolemia or diabetes mellitus. CONCLUSION: The present study adds to a growing body of literature that does not support the hypothesized relationship between C pneumoniae (or a phage-infected subset of C pneumoniae) and acute coronary syndromes. |
| format | Article |
| id | doaj-art-ca40b664ada84610a594bd150dabc0af |
| institution | Kabale University |
| issn | 1712-9532 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-ca40b664ada84610a594bd150dabc0af2025-02-03T01:01:40ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95322005-01-0116529830010.1155/2005/173147Chlamydial bacteriophage: No Role in Acute Coronary Events?David M Patrick0Karuna Karunakaran1Adrian R Levy2Kenneth Gin3Valencia Remple4Mei Chong5Heather Abbey6Laura Tarry7Caixia Shen8Robert C Brunham9University of British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, CanadaUniversity of British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Health Care and Epidemiology, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaUniversity of British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, CanadaUniversity of British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaUniversity of British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, CanadaUniversity of British Columbia Centre for Disease Control, University of British Columbia, Vancouver, British Columbia, CanadaBACKGROUND: A relationship between Chlamydia pneumoniae infection and acute coronary syndromes has not been consistently found in published studies. It has been hypothesized that a bacteriophage-infected subset of C pneumoniae may be uniquely equipped to promote atherosclerosis and acute coronary syndromes through the expression of phage genes. METHODS: The authors performed a pilot case-control study of acute coronary events. Case and control subjects were characterized demographically and according to recognized coronary risk factors. These subjects also provided serum for the detection of antibody to the elementary bodies of C pneumoniae and antibody to the Vp1 protein coded by the phage. Bivariate and multivariate comparisons were performed using statistics appropriate for paired analyses. RESULTS: Antibodies to C pneumoniae, Vp1 protein or both were not associated with acute coronary events by bivariate or multivariate analysis. As expected, case subjects were significantly more likely to have hypertension, hypercholesterolemia or diabetes mellitus. CONCLUSION: The present study adds to a growing body of literature that does not support the hypothesized relationship between C pneumoniae (or a phage-infected subset of C pneumoniae) and acute coronary syndromes.http://dx.doi.org/10.1155/2005/173147 |
| spellingShingle | David M Patrick Karuna Karunakaran Adrian R Levy Kenneth Gin Valencia Remple Mei Chong Heather Abbey Laura Tarry Caixia Shen Robert C Brunham Chlamydial bacteriophage: No Role in Acute Coronary Events? Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Chlamydial bacteriophage: No Role in Acute Coronary Events? |
| title_full | Chlamydial bacteriophage: No Role in Acute Coronary Events? |
| title_fullStr | Chlamydial bacteriophage: No Role in Acute Coronary Events? |
| title_full_unstemmed | Chlamydial bacteriophage: No Role in Acute Coronary Events? |
| title_short | Chlamydial bacteriophage: No Role in Acute Coronary Events? |
| title_sort | chlamydial bacteriophage no role in acute coronary events |
| url | http://dx.doi.org/10.1155/2005/173147 |
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