Regulation of anti-microbial autophagy by factors of the complement system
The complement system is a major component of innate immunity that participates in the defense of the host against a myriad of pathogenic microorganisms. Activation of complement allows for both local inflammatory response and physical elimination of microbes through phagocytosis or lysis. The syste...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2020-03-01
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| Series: | Microbial Cell |
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| Online Access: | http://microbialcell.com/researcharticles/2020a-viret-microbial-cell/ |
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| author | Christophe Viret Aurore Rozières Rémi Duclaux-Loras Gilles Boschetti Stéphane Nancey Mathias Faure |
| author_facet | Christophe Viret Aurore Rozières Rémi Duclaux-Loras Gilles Boschetti Stéphane Nancey Mathias Faure |
| author_sort | Christophe Viret |
| collection | DOAJ |
| description | The complement system is a major component of innate immunity that participates in the defense of the host against a myriad of pathogenic microorganisms. Activation of complement allows for both local inflammatory response and physical elimination of microbes through phagocytosis or lysis. The system is highly efficient and is therefore finely regulated. In addition to these well-established properties, recent works have revealed that components of the complement system can be involved in a variety of other functions including in autophagy, the conserved mechanism that allows for the targeting and degradation of cytosolic materials by the lysosomal pathway after confining them into specialized organelles called autophagosomes. Besides impacting cell death, development or metabolism, the complement factors-autophagy connection can greatly modulate the cell autonomous, anti-microbial activity of autophagy: xenophagy. Both surface receptor-ligand interactions and intracellular interactions are involved in the modulation of the autophagic response to intracellular microbes by complement factors. Here, we review works that relate to the recently discovered connections between factors of the complement system and the functioning of autophagy in the context of host-pathogen relationship. |
| format | Article |
| id | doaj-art-ca3f950bf79449aa9866edb9661d6003 |
| institution | OA Journals |
| issn | 2311-2638 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj-art-ca3f950bf79449aa9866edb9661d60032025-08-20T02:04:33ZengShared Science Publishers OGMicrobial Cell2311-26382020-03-01749310510.15698/mic2020.04.712Regulation of anti-microbial autophagy by factors of the complement systemChristophe Viret0Aurore Rozières1Rémi Duclaux-Loras2Gilles Boschetti3Stéphane Nancey4Mathias Faure5CIRI, Centre International de Recherche en Infectiologie, Team Autophagy Infection Immunity, Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.CIRI, Centre International de Recherche en Infectiologie, Team Autophagy Infection Immunity, Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.CIRI, Centre International de Recherche en Infectiologie, Team Autophagy Infection Immunity, Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.CIRI, Centre International de Recherche en Infectiologie, Team Autophagy Infection Immunity, Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.CIRI, Centre International de Recherche en Infectiologie, Team Autophagy Infection Immunity, Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.CIRI, Centre International de Recherche en Infectiologie, Team Autophagy Infection Immunity, Univ Lyon, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France.The complement system is a major component of innate immunity that participates in the defense of the host against a myriad of pathogenic microorganisms. Activation of complement allows for both local inflammatory response and physical elimination of microbes through phagocytosis or lysis. The system is highly efficient and is therefore finely regulated. In addition to these well-established properties, recent works have revealed that components of the complement system can be involved in a variety of other functions including in autophagy, the conserved mechanism that allows for the targeting and degradation of cytosolic materials by the lysosomal pathway after confining them into specialized organelles called autophagosomes. Besides impacting cell death, development or metabolism, the complement factors-autophagy connection can greatly modulate the cell autonomous, anti-microbial activity of autophagy: xenophagy. Both surface receptor-ligand interactions and intracellular interactions are involved in the modulation of the autophagic response to intracellular microbes by complement factors. Here, we review works that relate to the recently discovered connections between factors of the complement system and the functioning of autophagy in the context of host-pathogen relationship.http://microbialcell.com/researcharticles/2020a-viret-microbial-cell/autophagycomplementimmunityinfectionbacteriavirushomeostasis |
| spellingShingle | Christophe Viret Aurore Rozières Rémi Duclaux-Loras Gilles Boschetti Stéphane Nancey Mathias Faure Regulation of anti-microbial autophagy by factors of the complement system Microbial Cell autophagy complement immunity infection bacteria virus homeostasis |
| title | Regulation of anti-microbial autophagy by factors of the complement system |
| title_full | Regulation of anti-microbial autophagy by factors of the complement system |
| title_fullStr | Regulation of anti-microbial autophagy by factors of the complement system |
| title_full_unstemmed | Regulation of anti-microbial autophagy by factors of the complement system |
| title_short | Regulation of anti-microbial autophagy by factors of the complement system |
| title_sort | regulation of anti microbial autophagy by factors of the complement system |
| topic | autophagy complement immunity infection bacteria virus homeostasis |
| url | http://microbialcell.com/researcharticles/2020a-viret-microbial-cell/ |
| work_keys_str_mv | AT christopheviret regulationofantimicrobialautophagybyfactorsofthecomplementsystem AT aurorerozieres regulationofantimicrobialautophagybyfactorsofthecomplementsystem AT remiduclauxloras regulationofantimicrobialautophagybyfactorsofthecomplementsystem AT gillesboschetti regulationofantimicrobialautophagybyfactorsofthecomplementsystem AT stephanenancey regulationofantimicrobialautophagybyfactorsofthecomplementsystem AT mathiasfaure regulationofantimicrobialautophagybyfactorsofthecomplementsystem |