Correlation between serum lipoprotein associated phospholipase A2 level and renal damage in elders with type 2 diabetes mellitus
ObjectiveTo explore the correlation between serum lipoprotein associated phospholipase A2 （Lp-PLA2） and renal damage of diabetic kidney disease （DKD） in elders with type 2 diabetes mellitus （T2DM）.MethodsA total of 118 T2DM elders were recruited and divided into three groups according to urinary alb...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2022-06-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2022.06.002 |
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| Summary: | ObjectiveTo explore the correlation between serum lipoprotein associated phospholipase A2 （Lp-PLA2） and renal damage of diabetic kidney disease （DKD） in elders with type 2 diabetes mellitus （T2DM）.MethodsA total of 118 T2DM elders were recruited and divided into three groups according to urinary albumin/creatinine ratio.That is，group DM，<italic>n</italic>=52，urine albumin to creatinine ratio （UACR）<30 mg/g； group DKD1，<italic>n</italic>=38，30 mg/g<UACR<300 mg/g； group DKD2，<italic>n</italic>=28，UACR >300 mg/g.The differences of clinical parameters，renal function and Lp-PLA2 level were compared among three groups.And the correlation between Lp-PLA2 and clinical parameters was analyzed.Logistic regression analysis was performed for screening the risk factors of DKD in T2DM elders.ResultsCompared with simple DM group，the level of Lp-PLA2 was significantly higher in group DKD1/DKD2 ［DM group：（215.7±32.9） ng/mL； DKD1 group：（266.9±46.7） ng/mL； DKD2 group：（294.2±76.1） ng/mL］.With an advancing stage of diabetic nephropathy，the level of Lp-PLA2 rose gradually and the level of Lp-PLA2 was higher in group DKD2 than that in group DKD1 ［DKD1 group：（266.9±46.7） ng/mL； DKD2 group：（294.2±76.1） ng/mL］.Pearson’s correlation analysis revealed that the level of Lp-PLA2 was correlated positively with total cholesterol （TC，<italic>r</italic>=0.27，<italic>P</italic>=0.01），low-density lipoprotein-cholesterol （LDL-C，<italic>r</italic>=0.47，<italic>P</italic><0.01） and UACR （<italic>r</italic>=0.54，<italic>P</italic><0.01） and negatively with estimated glomerular filtration rate （eGFR，<italic>r</italic>=－0.61，<italic>P</italic><0.01）.Logistic regression analysis indicated that body mass index （BMI），HbA1c and Lp-PLA2 were the risk factors for predicting DKD in T2DM elders.ConclusionLp-PLA2 is probably involved in the occurrence and development of DKD.And regular monitoring of Lp-PLA2 has important clinical implications for preventing and treating DKD in T2DM elders. |
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| ISSN: | 1671-2390 |