Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive Keratoconus
In this work, the authors presented the techniques and the preliminary results at 6 months of a randomized controlled trial (NCT02117999) comparing a novel transepithelial corneal cross-linking protocol using iontophoresis with the Dresden protocol for the treatment of progressive keratoconus. At 6...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/7472542 |
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| author | Marco Lombardo Sebastiano Serrao Paolo Raffa Marianna Rosati Giuseppe Lombardo |
| author_facet | Marco Lombardo Sebastiano Serrao Paolo Raffa Marianna Rosati Giuseppe Lombardo |
| author_sort | Marco Lombardo |
| collection | DOAJ |
| description | In this work, the authors presented the techniques and the preliminary results at 6 months of a randomized controlled trial (NCT02117999) comparing a novel transepithelial corneal cross-linking protocol using iontophoresis with the Dresden protocol for the treatment of progressive keratoconus. At 6 months, there was a significant average improvement with an average flattening of the maximum simulated keratometry reading of 0.72±1.20 D (P=0.01); in addition, corrected distance visual acuity improved significantly (P=0.08) and spherical equivalent refraction was significantly less myopic (P=0.02) 6 months after transepithelial corneal cross-linking with iontophoresis. The novel protocol using iontophoresis showed comparable results with standard corneal cross-linking to halt progression of keratoconus during 6-month follow-up. Investigation of the long-term RCT outcomes are ongoing to verify the efficacy of this transepithelial corneal cross-linking protocol and to determine if it may be comparable with standard corneal cross-linking in the management of progressive keratoconus. |
| format | Article |
| id | doaj-art-ca367ada6c0947928a7806b7ac604048 |
| institution | DOAJ |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ca367ada6c0947928a7806b7ac6040482025-08-20T03:19:42ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/74725427472542Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive KeratoconusMarco Lombardo0Sebastiano Serrao1Paolo Raffa2Marianna Rosati3Giuseppe Lombardo4Fondazione G.B. Bietti, IRCCS, Via Livenza 3, 00198 Roma, ItalyFondazione G.B. Bietti, IRCCS, Via Livenza 3, 00198 Roma, ItalyDipartimento di Medicina Molecolare, Università di Padova, Via A. Gabelli 63, 35121 Padova, ItalyFondazione G.B. Bietti, IRCCS, Via Livenza 3, 00198 Roma, ItalyConsiglio Nazionale delle Ricerche, Istituto per i Processi Chimico-Fisici, Viale Stagno d’Alcontres 37, 98158 Messina, ItalyIn this work, the authors presented the techniques and the preliminary results at 6 months of a randomized controlled trial (NCT02117999) comparing a novel transepithelial corneal cross-linking protocol using iontophoresis with the Dresden protocol for the treatment of progressive keratoconus. At 6 months, there was a significant average improvement with an average flattening of the maximum simulated keratometry reading of 0.72±1.20 D (P=0.01); in addition, corrected distance visual acuity improved significantly (P=0.08) and spherical equivalent refraction was significantly less myopic (P=0.02) 6 months after transepithelial corneal cross-linking with iontophoresis. The novel protocol using iontophoresis showed comparable results with standard corneal cross-linking to halt progression of keratoconus during 6-month follow-up. Investigation of the long-term RCT outcomes are ongoing to verify the efficacy of this transepithelial corneal cross-linking protocol and to determine if it may be comparable with standard corneal cross-linking in the management of progressive keratoconus.http://dx.doi.org/10.1155/2016/7472542 |
| spellingShingle | Marco Lombardo Sebastiano Serrao Paolo Raffa Marianna Rosati Giuseppe Lombardo Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive Keratoconus Journal of Ophthalmology |
| title | Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive Keratoconus |
| title_full | Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive Keratoconus |
| title_fullStr | Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive Keratoconus |
| title_full_unstemmed | Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive Keratoconus |
| title_short | Novel Technique of Transepithelial Corneal Cross-Linking Using Iontophoresis in Progressive Keratoconus |
| title_sort | novel technique of transepithelial corneal cross linking using iontophoresis in progressive keratoconus |
| url | http://dx.doi.org/10.1155/2016/7472542 |
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