Neurosyphilis with concomitant cryptococcal meningitis in a patient with AIDS after COVID-19: a case report
Background: The common infection agents causing meningitis in patients with human immunodeficiency virus (HIV) include Cryptococcus neoformans and Treponema pallidum. Furthermore, there is an elevated risk of meningitis in patients with HIV concomitantly infected with SARS-CoV-2. Case presentatio...
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The Journal of Infection in Developing Countries
2025-06-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://www.jidc.org/index.php/journal/article/view/20529 |
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| author | Qi Wang Yunfei Pan |
| author_facet | Qi Wang Yunfei Pan |
| author_sort | Qi Wang |
| collection | DOAJ |
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Background: The common infection agents causing meningitis in patients with human immunodeficiency virus (HIV) include Cryptococcus neoformans and Treponema pallidum. Furthermore, there is an elevated risk of meningitis in patients with HIV concomitantly infected with SARS-CoV-2.
Case presentation: A 38-year-old male presented with headache and dizziness. After hospitalization, polymerase chain reaction test for SARS-CoV-2 with a nasopharyngeal swab was positive, and lumbar puncture revealed neurosyphilis with concomitant cryptococcal meningitis. He underwent nirmatrelvir-ritonavir, penicillin, antifungal and antiretroviral treatment. The patient had no other neurological symptoms and was stable during the 6-month follow-up period.
Conclusions: During the COVID-19 pandemic patients with HIV, particularly those who did not undergo antiretroviral therapy are at higher risk for severe infections, including central nervous system complications, due to their compromised immune systems.
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| format | Article |
| id | doaj-art-ca2dbf6032454f5ea8ca19d3430b5ae3 |
| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-ca2dbf6032454f5ea8ca19d3430b5ae32025-08-20T03:29:18ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802025-06-01190610.3855/jidc.20529Neurosyphilis with concomitant cryptococcal meningitis in a patient with AIDS after COVID-19: a case reportQi Wang0Yunfei Pan1Department of Infectious Diseases, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, ChinaDepartment of General Medicine, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Huzhou, China Background: The common infection agents causing meningitis in patients with human immunodeficiency virus (HIV) include Cryptococcus neoformans and Treponema pallidum. Furthermore, there is an elevated risk of meningitis in patients with HIV concomitantly infected with SARS-CoV-2. Case presentation: A 38-year-old male presented with headache and dizziness. After hospitalization, polymerase chain reaction test for SARS-CoV-2 with a nasopharyngeal swab was positive, and lumbar puncture revealed neurosyphilis with concomitant cryptococcal meningitis. He underwent nirmatrelvir-ritonavir, penicillin, antifungal and antiretroviral treatment. The patient had no other neurological symptoms and was stable during the 6-month follow-up period. Conclusions: During the COVID-19 pandemic patients with HIV, particularly those who did not undergo antiretroviral therapy are at higher risk for severe infections, including central nervous system complications, due to their compromised immune systems. https://www.jidc.org/index.php/journal/article/view/20529COVID-19human immunodeficiency viruscentral nervous system infectioncryptococcal meningitisneurosyphilis |
| spellingShingle | Qi Wang Yunfei Pan Neurosyphilis with concomitant cryptococcal meningitis in a patient with AIDS after COVID-19: a case report Journal of Infection in Developing Countries COVID-19 human immunodeficiency virus central nervous system infection cryptococcal meningitis neurosyphilis |
| title | Neurosyphilis with concomitant cryptococcal meningitis in a patient with AIDS after COVID-19: a case report |
| title_full | Neurosyphilis with concomitant cryptococcal meningitis in a patient with AIDS after COVID-19: a case report |
| title_fullStr | Neurosyphilis with concomitant cryptococcal meningitis in a patient with AIDS after COVID-19: a case report |
| title_full_unstemmed | Neurosyphilis with concomitant cryptococcal meningitis in a patient with AIDS after COVID-19: a case report |
| title_short | Neurosyphilis with concomitant cryptococcal meningitis in a patient with AIDS after COVID-19: a case report |
| title_sort | neurosyphilis with concomitant cryptococcal meningitis in a patient with aids after covid 19 a case report |
| topic | COVID-19 human immunodeficiency virus central nervous system infection cryptococcal meningitis neurosyphilis |
| url | https://www.jidc.org/index.php/journal/article/view/20529 |
| work_keys_str_mv | AT qiwang neurosyphiliswithconcomitantcryptococcalmeningitisinapatientwithaidsaftercovid19acasereport AT yunfeipan neurosyphiliswithconcomitantcryptococcalmeningitisinapatientwithaidsaftercovid19acasereport |