High prevalence of methotrexate intolerance in rheumatoid arthritis patients: a cross-sectional study

High prevalence of methotrexate intolerance in rheumatoid arthritis patients: a cross-sectional study

Abstract Background Methotrexate (MTX) is the most commonly used disease-modifying antirheumatic drug (DMARD) for treating rheumatoid arthritis (RA). However, MTX use is associated with gastrointestinal adverse effects in a number of patients. Early detection of MTX intolerance could help modify the...

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Main Authors: Harjit Singh Nalwa, Tushar Singh Barwal, Parul Chugh, Neha Singh, Neeraj Jain, Lalit Duggal, N. K. Ganguly, Ved Chaturvedi, Shivani Arora Mittal
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Rheumatology
Subjects:
Rheumatoid arthritis
Methotrexate
Questionnaire
Intolerance
Methotrexate intolerance severity score (MISS)
DAS-28
Online Access:https://doi.org/10.1186/s41927-025-00466-2
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