The efficacy and safety of intrathecal pemetrexed for leptomeningeal metastasis from non-small cell lung cancer: a single-arm meta-analysis of Chinese patients

The efficacy and safety of intrathecal pemetrexed for leptomeningeal metastasis from non-small cell lung cancer: a single-arm meta-analysis of Chinese patients

ObjectivesThe purpose of this meta-analysis is to evaluate the safety and effectiveness of intrathecal pemetrexed (IP) in patients with non-small cell lung cancer with leptomeningeal metastasis (NSCLC-LM).MethodsA systematic search of PubMed, the Cochrane library, Embase, and ClinicalTrials.gov data...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yushi Zhao, Xueqin Gao, Yong Han
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-06-01
Series:	Frontiers in Oncology
Subjects:	pemetrexed non-small cell lung cancer leptomeningeal metastasis meta-analysis efficacy safety
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1543416/full
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Correction: The efficacy and safety of intrathecal pemetrexed for leptomeningeal metastasis from non-small cell lung cancer: a single-arm meta-analysis of Chinese patients
by: Yushi Zhao, et al.
Published: (2025-07-01)

Intrathecal pemetrexed efficacy and cerebrospinal fluid tumor marker response in refractory leptomeningeal metastasis of non-small-cell lung cancer: a single-arm phase II trial
by: Qingsheng Xu, et al.
Published: (2025-05-01)

Intrathecal pemetrexed chemotherapy combined with systemic therapy in patients with non-small cell lung cancer and leptomeningeal metastases: a retrospective study
by: Wenjuan Zhong, et al.
Published: (2025-04-01)

Combination of antiangiogenic and systemic therapy in advanced non-small cell lung cancer: before and after progression to leptomeningeal metastasis
by: Xiao-dan Zhu, et al.
Published: (2025-04-01)

RESULTS OF TREATMENT OF PATIENTS WITH LOCALLY ADVANCED AND METASTATIC NON-SQUAMOUS CELL NON-SMALL-CELL LUNG CARCINOMA WITH PEMETREXED (BY OWN EXPERIENCE)
by: L. Yu. Vladimirova, et al.
Published: (2016-04-01)

Leptomeningeal metastasis with sturge-weber syndrome-like gyriform calcification on imaging: a case report
by: Yang Liu, et al.
Published: (2025-07-01)

Experience of pemetrexed in maintenance therapy for metastatic lung adenocarcinoma
by: L. Yu. Vladimirova, et al.
Published: (2021-03-01)

Case report: Leptomeningeal metastasis of advanced nasopharyngeal carcinoma treated with chemoimmunotherapy
by: Mengting Shi, et al.
Published: (2023-12-01)

Leptomeningeal metastasis in triple-negative breast cancer: a retrospective study
by: Yun-Yi Wang, et al.
Published: (2025-08-01)

Maintenance pemetrexed in nonsmall cell lung carcinoma: Outcome analysis from a tertiary care center
by: Avinash Vijaykumar Pandey, et al.
Published: (2015-01-01)

PHARMACOECONOMIC EVALUATION OF THE MEDICINAL PRODUCTS ERLOTINIB, DOCETAXEL, PEMETREXED AND GEFITINIB IN THE SECOND-LINE TREATMENT OF LOCALLY-ADVANCED OR METASTATIC NON-SMALL-CELL LUNG CANCER
by: A. U. Kulikov
Published: (2015-03-01)

Rare leptomeningeal recurrence of mucinous ovarian carcinoma
by: Gabrielle LeBlanc, et al.
Published: (2025-06-01)

The bloomy rind sign: A key imaging clue in early leptomeningeal carcinomatosis from lung cancer—A case report
by: Karim Haddar, et al.
Published: (2025-08-01)

Evaluation of CE-MATRIX-Enhanced FLAIR imaging in the detection of leptomeningeal metastasis
by: Junhui Yuan, et al.
Published: (2025-04-01)

Diffuse Leptomeningeal Glioneuronal Tumor in an Adult: A Diagnostic Challenge
by: Mukesh Kumar Bhaskar, et al.
Published: (2022-01-01)

Acute pancreatitis caused by pemetrexed, carboplatin, and gemcitabine in a patient with lung cancer: A rare case report
by: Vishal Kulkarni, et al.
Published: (2019-01-01)

Integration of continuous lumbar drainage and third-generation EGFR-TKI in managing leptomeningeal metastasis-induced life-threatening intracranial hypertension: a case report
by: Lei Wang, et al.
Published: (2025-05-01)

A rare presentation of the diffuse dermal mucinosis in adenocarcinoma of the lungs treated with pembrolizumab and pemetrexed
by: Karen Koch, MBChB (UCT), FCDerm (SA), FRACP, MMed (Derm), et al.
Published: (2025-07-01)

Real-world analysis of survival outcomes in advanced EGFR-mutant NSCLC patients treated with platinum-pemetrexed after EGFR-TKI treatment failure
by: Zong-Han Yao, et al.
Published: (2025-08-01)

Treatment of Leptomeningeal Disease with Tepotinib in a Patient with Lung Adenocarcinoma Harboring MET Exon 14 Skipping Mutation Presenting with Extensive Metastasis Involving Duodenum
by: Jacquelyn Shugarts, et al.
Published: (2025-06-01)

Postmarketing safety evaluation of pemetrexed using FAERS and JADER databases
by: Luo Lv, et al.
Published: (2025-05-01)

Diagnosing primary malignancy in leptomeningeal carcinomatosis by using CSF cytology and immunohistochemistry: A case report
by: Navaneeth Reddy Hasthavaram, et al.
Published: (2020-01-01)

Intrathecal Trastuzumab as a Novel Simplified Therapeutic Strategy for Isolated Metastases in the Leptomeninges in HER2-Positive Breast Cancer: A Case Report and Review of Literature
by: Lokesh K. Nagendrappa, et al.

Significant clinical benefit of pemetrexed-based chemotherapy for advanced diffuse malignant peritoneal mesothelioma: A case presentation
by: Milena Peitl, et al.
Published: (2017-01-01)

Survival outcomes among patients with breast cancer and leptomeningeal disease
by: Badr Id Said, et al.
Published: (2025-07-01)

Primary diffuse leptomeningeal melanomatosis in a child with a clinical presentation mimicking meningitis: case report and review of literature
by: P. V. Sudharsan, et al.
Published: (2025-05-01)

Leptomeningeal cyst in an adult following childhood trauma: a case report
by: Bereket Girum Beyene, MD, et al.
Published: (2025-05-01)

Metastasis of Small Cell Lung Cancer to the External Auditory Canal: A Case Report
by: Toshiyuki Ito, et al.
Published: (2025-04-01)

Prognostic value of lymph node ratio in patients with non-small cell lung cancer: a systematic review and meta-analysis
by: Junhuang Zheng, et al.
Published: (2025-07-01)

An Uncommon Presentation of Leptomeningeal Metastases in Breast Carcinoma Detected by F-18 FDG PET/CT
by: Gavini Surya, et al.
Published: (2022-09-01)

Generalized herpes zoster and cutaneous metastasis during chemotherapy for non‐small cell lung cancer: A case report
by: Naoya Yasokawa, et al.
Published: (2021-01-01)

A web-based prediction model for brain metastasis in non-small cell lung cancer patients
by: Jianing Chen, et al.
Published: (2025-07-01)

Primary Diffuse Leptomeningeal Melanomatosis Leading to Raised Intracranial Pressure in a Pediatric Patient
by: Shiva Sareh, et al.
Published: (2025-02-01)

Multicentric Leptomeningeal Glioblastoma Mimicking Meningioma: A Case Report and Systematic Review
by: Rakesh Mishra, et al.

Efficacy and safety of upfront radiotherapy with immune checkpoint inhibitors for brain metastasis in non-small cell lung cancer
by: Yu Tanaka, et al.
Published: (2025-01-01)

Local intracerebral form of diffuse leptomeningeal glioneuronal tumor – a new entity of the group of epileptogenic neoplasms?
by: V. S. Khalilov, et al.
Published: (2024-07-01)

Metagenomics and Non‐Targeted Metabolomics Reveal the Role of Gut Microbiota and Its Metabolites in Brain Metastasis of Non‐Small Cell Lung Cancer
by: Chen‐Guang Liu, et al.
Published: (2025-04-01)

Case Report: Mimicking benignity: hepatic sinusoidal metastasis masquerading as diffuse liver disease in small cell lung cancer
by: Lujiao Chen, et al.
Published: (2025-08-01)

Lung Adenocarcinoma With Extensive Vascular Invasion and Retinal Metastasis: A Case Report
by: Bassem Alhariri, et al.
Published: (2025-06-01)

Comprehensive Analysis of Lung Cancer Metastasis: Sites, Rates, Survival, and Risk Factors—A Systematic Review and Meta‐Analysis
by: Shilin Wang, et al.
Published: (2025-07-01)