Tracing histoplasmosis genomic epidemiology and species occurrence across the USA
Histoplasmosis is an endemic mycosis in North America frequently reported along the Ohio and Mississippi River Valleys, although autochthonous cases occur in non-endemic areas. In the United States, the disease is provoked by two genetically distinct clades of Histoplasma capsulatum sensu lato, Hist...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2315960 |
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| author | Bernardo Guerra Tenório Daniel R. Kollath Lalitha Gade Anastasia P. Litvintseva Tom Chiller Jeff S. Jenness Jason E. Stajich Daniel R. Matute Andrew S. Hanzlicek Bridget M. Barker Marcus de Melo Teixeira |
| author_facet | Bernardo Guerra Tenório Daniel R. Kollath Lalitha Gade Anastasia P. Litvintseva Tom Chiller Jeff S. Jenness Jason E. Stajich Daniel R. Matute Andrew S. Hanzlicek Bridget M. Barker Marcus de Melo Teixeira |
| author_sort | Bernardo Guerra Tenório |
| collection | DOAJ |
| description | Histoplasmosis is an endemic mycosis in North America frequently reported along the Ohio and Mississippi River Valleys, although autochthonous cases occur in non-endemic areas. In the United States, the disease is provoked by two genetically distinct clades of Histoplasma capsulatum sensu lato, Histoplasma mississippiense (Nam1) and H. ohiense (Nam2). To bridge the molecular epidemiological gap, we genotyped 93 Histoplasma isolates (62 novel genomes) including clinical, environmental, and veterinarian samples from a broader geographical range by whole-genome sequencing, followed by evolutionary and species niche modelling analyses. We show that histoplasmosis is caused by two major lineages, H. ohiense and H. mississippiense; with sporadic cases caused by H. suramericanum in California and Texas. While H. ohiense is prevalent in eastern states, H. mississipiense was found to be prevalent in the central and western portions of the United States, but also geographically overlapping in some areas suggesting that these species might co-occur. Species Niche Modelling revealed that H. ohiense thrives in places with warmer and drier conditions, while H. mississippiense is endemic to areas with cooler temperatures and more precipitation. In addition, we predicted multiple areas of secondary contact zones where the two species co-occur, potentially facilitating gene exchange and hybridization. This study provides the most comprehensive understanding of the genomic epidemiology of histoplasmosis in the USA and lays a blueprint for the study of invasive fungal diseases. |
| format | Article |
| id | doaj-art-ca2000f8172542a2aa0c068e90e1e473 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-ca2000f8172542a2aa0c068e90e1e4732025-08-20T02:37:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2315960Tracing histoplasmosis genomic epidemiology and species occurrence across the USABernardo Guerra Tenório0Daniel R. Kollath1Lalitha Gade2Anastasia P. Litvintseva3Tom Chiller4Jeff S. Jenness5Jason E. Stajich6Daniel R. Matute7Andrew S. Hanzlicek8Bridget M. Barker9Marcus de Melo Teixeira10Faculty of Medicine, University of Brasília, Brasília, BrazilPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USAMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USAMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USAMycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, USASchool of Forestry, Northern Arizona University, Flagstaff, AZ, USADepartment of Microbiology & Plant Pathology and Institute for Integrative Genome Biology, University of California, Riverside, CA, USABiology Department, University of North Carolina, Chapel Hill, NC, USAMiraVista Diagnostics, Indianapolis, IN, USAPathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USAFaculty of Medicine, University of Brasília, Brasília, BrazilHistoplasmosis is an endemic mycosis in North America frequently reported along the Ohio and Mississippi River Valleys, although autochthonous cases occur in non-endemic areas. In the United States, the disease is provoked by two genetically distinct clades of Histoplasma capsulatum sensu lato, Histoplasma mississippiense (Nam1) and H. ohiense (Nam2). To bridge the molecular epidemiological gap, we genotyped 93 Histoplasma isolates (62 novel genomes) including clinical, environmental, and veterinarian samples from a broader geographical range by whole-genome sequencing, followed by evolutionary and species niche modelling analyses. We show that histoplasmosis is caused by two major lineages, H. ohiense and H. mississippiense; with sporadic cases caused by H. suramericanum in California and Texas. While H. ohiense is prevalent in eastern states, H. mississipiense was found to be prevalent in the central and western portions of the United States, but also geographically overlapping in some areas suggesting that these species might co-occur. Species Niche Modelling revealed that H. ohiense thrives in places with warmer and drier conditions, while H. mississippiense is endemic to areas with cooler temperatures and more precipitation. In addition, we predicted multiple areas of secondary contact zones where the two species co-occur, potentially facilitating gene exchange and hybridization. This study provides the most comprehensive understanding of the genomic epidemiology of histoplasmosis in the USA and lays a blueprint for the study of invasive fungal diseases.https://www.tandfonline.com/doi/10.1080/22221751.2024.2315960Histoplasmosismolecular epidemiologyHistoplasma ohienseHistoplasma mississippiensegenomicsspecies distribution modelling |
| spellingShingle | Bernardo Guerra Tenório Daniel R. Kollath Lalitha Gade Anastasia P. Litvintseva Tom Chiller Jeff S. Jenness Jason E. Stajich Daniel R. Matute Andrew S. Hanzlicek Bridget M. Barker Marcus de Melo Teixeira Tracing histoplasmosis genomic epidemiology and species occurrence across the USA Emerging Microbes and Infections Histoplasmosis molecular epidemiology Histoplasma ohiense Histoplasma mississippiense genomics species distribution modelling |
| title | Tracing histoplasmosis genomic epidemiology and species occurrence across the USA |
| title_full | Tracing histoplasmosis genomic epidemiology and species occurrence across the USA |
| title_fullStr | Tracing histoplasmosis genomic epidemiology and species occurrence across the USA |
| title_full_unstemmed | Tracing histoplasmosis genomic epidemiology and species occurrence across the USA |
| title_short | Tracing histoplasmosis genomic epidemiology and species occurrence across the USA |
| title_sort | tracing histoplasmosis genomic epidemiology and species occurrence across the usa |
| topic | Histoplasmosis molecular epidemiology Histoplasma ohiense Histoplasma mississippiense genomics species distribution modelling |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2315960 |
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