INFLUENCE OF ANTIBODIES AGAINST CTLA-4 AND PD-1 UPON QUANTITIES OF THEIR TARGET RECEPTORS

INFLUENCE OF ANTIBODIES AGAINST CTLA-4 AND PD-1 UPON QUANTITIES OF THEIR TARGET RECEPTORS

Inhibitory receptors CTLA-4 and PD-1 (immune checkpoints) play a key role in regulation of immune reactions. They suppress excessive immune response against pathogenic microbes and prevent autoimmune reactions. The immune checkpoints are targets of the modern effective therapy based on human and hum...

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Bibliographic Details
Main Authors: I. O. Chikileva, I. Zh. Shubina, I. V. Samoylenko, A. V. Karaulov, M. V. Kiselevsky
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2019-01-01
Series:Медицинская иммунология
Subjects:
immune checkpoints
inhibitory immune receptors
ctla-4
pd-1
ipilimumab
nivolumab
cancer immunotherapy
Online Access:https://www.mimmun.ru/mimmun/article/view/1699
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