Protocol for inducing epidermis-specific gene deletion and establishing a UVB-irradiated skin inflammation model

Protocol for inducing epidermis-specific gene deletion and establishing a UVB-irradiated skin inflammation model

Summary: When skin is exposed to ultraviolet B (UVB) radiation, damaged keratinocytes release double-stranded RNA to trigger an inflammatory response. Here, we present a protocol to induce epidermal-specific Zfp750 gene-deficient mice and establish a UVB-induced skin inflammation model. We detail pr...

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Bibliographic Details
Main Authors: Ye Liu, George L. Sen
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:STAR Protocols
Subjects:
Genetics
Immunology
Model Organisms
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166725001078
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