Is human cytomegalovirus a potential risk factor for mood disorders? A systematic review and meta-analysis
Mood disorders are among the common mental disorders worldwide. Because of the persistence of cytomegalovirus (CMV) in the body and nervous system, this virus can be activated when the immune system is weakened and continues to exert its destructive effects throughout life. This study aimed to inves...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-11-01
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| Series: | Indian Journal of Psychiatry |
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| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_672_23 |
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| author | Zahra Yousefian Seyedeh Masoumeh Seyedhosseini Tamijani Hamed Ghazvini Farzan Kheirkhah Raheleh Rafaiee Tahoora Mousavi |
| author_facet | Zahra Yousefian Seyedeh Masoumeh Seyedhosseini Tamijani Hamed Ghazvini Farzan Kheirkhah Raheleh Rafaiee Tahoora Mousavi |
| author_sort | Zahra Yousefian |
| collection | DOAJ |
| description | Mood disorders are among the common mental disorders worldwide. Because of the persistence of cytomegalovirus (CMV) in the body and nervous system, this virus can be activated when the immune system is weakened and continues to exert its destructive effects throughout life. This study aimed to investigate the seroprevalence and association of human cytomegalovirus with mood disorders. Eligible articles were extracted using online international databases Science Direct, Medline, Web of Science, Scopus, and Google Scholar between 2000 and 2023. After quality assessment and specific inclusion and exclusion criteria, a total of eight eligible articles were included in the meta-analysis. Our finding showed that the seropositivity of CMV in mood disorders was 51.6% (95% CI; 42.8–60.4). There were statistical differences between mood disorders and control groups regarding the seropositivity of CMV 1.327% (95% CI; 13.27–10.45). The results of the publication bias using the Egger test confirmed no publication bias in each sub-group. The results of this meta-analysis study demonstrated that CMV infection might have associations with the incidence of mood disorders. Furthermore, we found that there were statistical differences between mood disorders and control groups regarding the seropositivity of CMV. |
| format | Article |
| id | doaj-art-ca15e26599c84b5686d7f4de6a184578 |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-ca15e26599c84b5686d7f4de6a1845782025-01-26T08:55:41ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942023-11-0165111104111110.4103/indianjpsychiatry.indianjpsychiatry_672_23Is human cytomegalovirus a potential risk factor for mood disorders? A systematic review and meta-analysisZahra YousefianSeyedeh Masoumeh Seyedhosseini TamijaniHamed GhazviniFarzan KheirkhahRaheleh RafaieeTahoora MousaviMood disorders are among the common mental disorders worldwide. Because of the persistence of cytomegalovirus (CMV) in the body and nervous system, this virus can be activated when the immune system is weakened and continues to exert its destructive effects throughout life. This study aimed to investigate the seroprevalence and association of human cytomegalovirus with mood disorders. Eligible articles were extracted using online international databases Science Direct, Medline, Web of Science, Scopus, and Google Scholar between 2000 and 2023. After quality assessment and specific inclusion and exclusion criteria, a total of eight eligible articles were included in the meta-analysis. Our finding showed that the seropositivity of CMV in mood disorders was 51.6% (95% CI; 42.8–60.4). There were statistical differences between mood disorders and control groups regarding the seropositivity of CMV 1.327% (95% CI; 13.27–10.45). The results of the publication bias using the Egger test confirmed no publication bias in each sub-group. The results of this meta-analysis study demonstrated that CMV infection might have associations with the incidence of mood disorders. Furthermore, we found that there were statistical differences between mood disorders and control groups regarding the seropositivity of CMV.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_672_23cytomegalovirusmeta-analysismood disordersseroprevalence |
| spellingShingle | Zahra Yousefian Seyedeh Masoumeh Seyedhosseini Tamijani Hamed Ghazvini Farzan Kheirkhah Raheleh Rafaiee Tahoora Mousavi Is human cytomegalovirus a potential risk factor for mood disorders? A systematic review and meta-analysis Indian Journal of Psychiatry cytomegalovirus meta-analysis mood disorders seroprevalence |
| title | Is human cytomegalovirus a potential risk factor for mood disorders? A systematic review and meta-analysis |
| title_full | Is human cytomegalovirus a potential risk factor for mood disorders? A systematic review and meta-analysis |
| title_fullStr | Is human cytomegalovirus a potential risk factor for mood disorders? A systematic review and meta-analysis |
| title_full_unstemmed | Is human cytomegalovirus a potential risk factor for mood disorders? A systematic review and meta-analysis |
| title_short | Is human cytomegalovirus a potential risk factor for mood disorders? A systematic review and meta-analysis |
| title_sort | is human cytomegalovirus a potential risk factor for mood disorders a systematic review and meta analysis |
| topic | cytomegalovirus meta-analysis mood disorders seroprevalence |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_672_23 |
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