Radiation-induced morphea of the breast – characterization and treatment of fibroblast dysfunction with repurposed mesalazine

Radiation-induced morphea of the breast – characterization and treatment of fibroblast dysfunction with repurposed mesalazine

Abstract Radiation-induced morphea (RIM) is a rare complication of radiotherapy presenting as inflammatory fibrosis, most commonly reported in breast cancer patients. As underlying disease mechanisms are not well understood, targeted therapies are lacking. Since fibroblasts are the key mediators of...

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Bibliographic Details
Main Authors: Stephan R. Künzel, Erik Klapproth, Nick Zimmermann, Susanne Kämmerer, Mario Schubert, Karolina Künzel, Maximilian Hoffmann, Stephan Drukewitz, Anne Vehlow, Jiri Eitler, Marieke Arriens, Jessica Thiel, Romy Kronstein-Wiedemann, Maximiliane Tietze, Stefan Beissert, Bertold Renner, Ali El-Armouche, Claudia Günther
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Fibrosis
Morphea
Drug repurposing
Breast cancer
Mesalazine
Online Access:https://doi.org/10.1038/s41598-024-74206-w
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