Changes in basophil reactivity and synthesis of specific immunoglobulins E influenced by allergen-immunotherapy
The study focused on spontaneous and allergen-induced basophil activation (BAT) as well as on specific IgE indicators to major meadow grass pollen allergens on the background of allergen-immunotherapy (AIT) in patients sensitized to weed pollen. The study revealed that the specific IgE indicators to...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Association of Paediatric Allergists and Immunologists of Russia (APAIR)
2023-03-01
|
| Series: | Аллергология и Иммунология в Педиатрии |
| Subjects: | |
| Online Access: | https://adair.elpub.ru/jour/article/view/4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849694816245383168 |
|---|---|
| author | L. Yu. Barycheva L. V. Dushina Yu. N. Medvedenko |
| author_facet | L. Yu. Barycheva L. V. Dushina Yu. N. Medvedenko |
| author_sort | L. Yu. Barycheva |
| collection | DOAJ |
| description | The study focused on spontaneous and allergen-induced basophil activation (BAT) as well as on specific IgE indicators to major meadow grass pollen allergens on the background of allergen-immunotherapy (AIT) in patients sensitized to weed pollen. The study revealed that the specific IgE indicators to major ragweed allergens (nAmb a 1) and wormwood (nArt v 1) allergens, as well as the ratios of spec. IgE nAmb a 1/gen. IgE, and spec. IgE nArt v 1/gen. IgE do not change after 2 courses of pre-seasonal ASIT. There was a decrease detected in BAT indicators under the effect of ASIT. An early decrease in the BAT stimulation index (BAT IC) was shown to be more common for patients with positive treatment outcomes. |
| format | Article |
| id | doaj-art-ca146db1f6294cb0a8663292d3f79ea9 |
| institution | DOAJ |
| issn | 2500-1175 2712-7958 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | Association of Paediatric Allergists and Immunologists of Russia (APAIR) |
| record_format | Article |
| series | Аллергология и Иммунология в Педиатрии |
| spelling | doaj-art-ca146db1f6294cb0a8663292d3f79ea92025-08-20T03:19:57ZrusAssociation of Paediatric Allergists and Immunologists of Russia (APAIR)Аллергология и Иммунология в Педиатрии2500-11752712-79582023-03-0101152310.24412/2500-1175-2021-1-15-233Changes in basophil reactivity and synthesis of specific immunoglobulins E influenced by allergen-immunotherapyL. Yu. Barycheva0L. V. Dushina1Yu. N. Medvedenko2Federal State Budgetary Institution for Higher Education Stavropol State Medical University of the Ministry of Health Russian Federation; Stavropol Regional Clinical&Counseling Diagnostics CenterFederal State Budgetary Institution for Higher Education Stavropol State Medical University of the Ministry of Health Russian FederationFederal State Budgetary Institution for Higher Education Stavropol State Medical University of the Ministry of Health Russian Federation; Stavropol Regional Clinical&Counseling Diagnostics CenterThe study focused on spontaneous and allergen-induced basophil activation (BAT) as well as on specific IgE indicators to major meadow grass pollen allergens on the background of allergen-immunotherapy (AIT) in patients sensitized to weed pollen. The study revealed that the specific IgE indicators to major ragweed allergens (nAmb a 1) and wormwood (nArt v 1) allergens, as well as the ratios of spec. IgE nAmb a 1/gen. IgE, and spec. IgE nArt v 1/gen. IgE do not change after 2 courses of pre-seasonal ASIT. There was a decrease detected in BAT indicators under the effect of ASIT. An early decrease in the BAT stimulation index (BAT IC) was shown to be more common for patients with positive treatment outcomes.https://adair.elpub.ru/jour/article/view/4pollinosisallergen-immunotherapyspecific igebasophil reactivity |
| spellingShingle | L. Yu. Barycheva L. V. Dushina Yu. N. Medvedenko Changes in basophil reactivity and synthesis of specific immunoglobulins E influenced by allergen-immunotherapy Аллергология и Иммунология в Педиатрии pollinosis allergen-immunotherapy specific ige basophil reactivity |
| title | Changes in basophil reactivity and synthesis of specific immunoglobulins E influenced by allergen-immunotherapy |
| title_full | Changes in basophil reactivity and synthesis of specific immunoglobulins E influenced by allergen-immunotherapy |
| title_fullStr | Changes in basophil reactivity and synthesis of specific immunoglobulins E influenced by allergen-immunotherapy |
| title_full_unstemmed | Changes in basophil reactivity and synthesis of specific immunoglobulins E influenced by allergen-immunotherapy |
| title_short | Changes in basophil reactivity and synthesis of specific immunoglobulins E influenced by allergen-immunotherapy |
| title_sort | changes in basophil reactivity and synthesis of specific immunoglobulins e influenced by allergen immunotherapy |
| topic | pollinosis allergen-immunotherapy specific ige basophil reactivity |
| url | https://adair.elpub.ru/jour/article/view/4 |
| work_keys_str_mv | AT lyubarycheva changesinbasophilreactivityandsynthesisofspecificimmunoglobulinseinfluencedbyallergenimmunotherapy AT lvdushina changesinbasophilreactivityandsynthesisofspecificimmunoglobulinseinfluencedbyallergenimmunotherapy AT yunmedvedenko changesinbasophilreactivityandsynthesisofspecificimmunoglobulinseinfluencedbyallergenimmunotherapy |