Treatment and control of blood pressure in Welsh patients with and without depression: A study of whole-population electronic health records.
<h4>Background</h4>To explore differences in blood pressure treatment and control in patients with and without depression and a diagnosis of hypertension (HTN). Also to examine the possible impact of sex, socio-economic status (deprivation) and location of residence on any differences.&l...
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0326583 |
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| author | Elizabeth A Ellins Richard Summers Carla White Ann John David P J Osborn Keith Lloyd Ashley Akbari Michael B Gravenor Julian P Halcox |
| author_facet | Elizabeth A Ellins Richard Summers Carla White Ann John David P J Osborn Keith Lloyd Ashley Akbari Michael B Gravenor Julian P Halcox |
| author_sort | Elizabeth A Ellins |
| collection | DOAJ |
| description | <h4>Background</h4>To explore differences in blood pressure treatment and control in patients with and without depression and a diagnosis of hypertension (HTN). Also to examine the possible impact of sex, socio-economic status (deprivation) and location of residence on any differences.<h4>Methods</h4>A retrospective observational cohort study (2010-2019) using individual level linked anonymised routinely-collected electronic health record (EHR) data sources was carried out. Patients with a prior or new diagnosis of hypertension, with and without depression were included. Outcome variables were prescription of antihypertensive therapy (AHT) within one year of entering the study for prior HTN or post for new HTN and documentation of blood pressure <140/90 mmHg. Logistic regression was used to explore the association between depression and outcome variables adjusting for sex, age group, deprivation, location of residence and other risk factors.<h4>Results</h4>Depression was associated with higher likelihood of AHT prescription in both prior (OR 1.71 95%CI 1.64-1.78 p < 0.001) and new HTN patients (OR 2.67 95%CI 2.38-3.00 p < 0.001). Similarly, depression was associated with successful blood pressure control in both prior (OR 1.42 95%CI 1.37-1.46 p < 0.001) and new HTN (OR 1.23 95%CI 1.08-1.40 p < 0.001). Females were less likely to be prescribed AHT than males, mainly driven by non-depressed females in both HTN groups. Depressed females were the most likely to have controlled blood pressure in both HTN groups.<h4>Conclusion</h4>Patients with depression are more likely to be prescribed AHT and have documented blood pressure control. Sex differences existed in treatment and control, indicating opportunities for potential improvements in these areas. |
| format | Article |
| id | doaj-art-ca1389e63bec42819e320e67f5fa62a5 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-ca1389e63bec42819e320e67f5fa62a52025-08-20T03:29:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01206e032658310.1371/journal.pone.0326583Treatment and control of blood pressure in Welsh patients with and without depression: A study of whole-population electronic health records.Elizabeth A EllinsRichard SummersCarla WhiteAnn JohnDavid P J OsbornKeith LloydAshley AkbariMichael B GravenorJulian P Halcox<h4>Background</h4>To explore differences in blood pressure treatment and control in patients with and without depression and a diagnosis of hypertension (HTN). Also to examine the possible impact of sex, socio-economic status (deprivation) and location of residence on any differences.<h4>Methods</h4>A retrospective observational cohort study (2010-2019) using individual level linked anonymised routinely-collected electronic health record (EHR) data sources was carried out. Patients with a prior or new diagnosis of hypertension, with and without depression were included. Outcome variables were prescription of antihypertensive therapy (AHT) within one year of entering the study for prior HTN or post for new HTN and documentation of blood pressure <140/90 mmHg. Logistic regression was used to explore the association between depression and outcome variables adjusting for sex, age group, deprivation, location of residence and other risk factors.<h4>Results</h4>Depression was associated with higher likelihood of AHT prescription in both prior (OR 1.71 95%CI 1.64-1.78 p < 0.001) and new HTN patients (OR 2.67 95%CI 2.38-3.00 p < 0.001). Similarly, depression was associated with successful blood pressure control in both prior (OR 1.42 95%CI 1.37-1.46 p < 0.001) and new HTN (OR 1.23 95%CI 1.08-1.40 p < 0.001). Females were less likely to be prescribed AHT than males, mainly driven by non-depressed females in both HTN groups. Depressed females were the most likely to have controlled blood pressure in both HTN groups.<h4>Conclusion</h4>Patients with depression are more likely to be prescribed AHT and have documented blood pressure control. Sex differences existed in treatment and control, indicating opportunities for potential improvements in these areas.https://doi.org/10.1371/journal.pone.0326583 |
| spellingShingle | Elizabeth A Ellins Richard Summers Carla White Ann John David P J Osborn Keith Lloyd Ashley Akbari Michael B Gravenor Julian P Halcox Treatment and control of blood pressure in Welsh patients with and without depression: A study of whole-population electronic health records. PLoS ONE |
| title | Treatment and control of blood pressure in Welsh patients with and without depression: A study of whole-population electronic health records. |
| title_full | Treatment and control of blood pressure in Welsh patients with and without depression: A study of whole-population electronic health records. |
| title_fullStr | Treatment and control of blood pressure in Welsh patients with and without depression: A study of whole-population electronic health records. |
| title_full_unstemmed | Treatment and control of blood pressure in Welsh patients with and without depression: A study of whole-population electronic health records. |
| title_short | Treatment and control of blood pressure in Welsh patients with and without depression: A study of whole-population electronic health records. |
| title_sort | treatment and control of blood pressure in welsh patients with and without depression a study of whole population electronic health records |
| url | https://doi.org/10.1371/journal.pone.0326583 |
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