Osteopontin at the Crossroads of Inflammation and Tumor Progression
Complex interactions between tumor and host cells regulate systemic tumor dissemination, a process that begins early at the primary tumor site and goes on until tumor cells detach themselves from the tumor mass and start migrating into the blood or lymphatic vessels. Metastatic cells colonize the ta...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/4049098 |
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| author | Luigi Mario Castello Davide Raineri Livia Salmi Nausicaa Clemente Rosanna Vaschetto Marco Quaglia Massimiliano Garzaro Sergio Gentilli Paolo Navalesi Vincenzo Cantaluppi Umberto Dianzani Anna Aspesi Annalisa Chiocchetti |
| author_facet | Luigi Mario Castello Davide Raineri Livia Salmi Nausicaa Clemente Rosanna Vaschetto Marco Quaglia Massimiliano Garzaro Sergio Gentilli Paolo Navalesi Vincenzo Cantaluppi Umberto Dianzani Anna Aspesi Annalisa Chiocchetti |
| author_sort | Luigi Mario Castello |
| collection | DOAJ |
| description | Complex interactions between tumor and host cells regulate systemic tumor dissemination, a process that begins early at the primary tumor site and goes on until tumor cells detach themselves from the tumor mass and start migrating into the blood or lymphatic vessels. Metastatic cells colonize the target organs and are capable of surviving and growing at distant sites. In this context, osteopontin (OPN) appears to be a key determinant of the crosstalk between cancer cells and the host microenvironment, which in turn modulates immune evasion. OPN is overexpressed in several human carcinomas and has been implicated in inflammation, tumor progression, and metastasis. Thus, it represents one of the most attracting targets for cancer therapy. Within the tumor mass, OPN is secreted in various forms either by the tumor itself or by stroma cells, and it can exert either pro- or antitumorigenic effects according to the cell type and tumor microenvironment. Thus, targeting OPN for therapeutic purposes needs to take into account the heterogeneous functions of the multiple OPN forms with regard to cancer formation and progression. In this review, we will describe the role of systemic, tumor-derived, and stroma-derived OPN, highlighting its pivotal role at the crossroads of inflammation and tumor progression. |
| format | Article |
| id | doaj-art-ca13613323b94cccb5482b749d06b42b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ca13613323b94cccb5482b749d06b42b2025-02-03T01:10:43ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/40490984049098Osteopontin at the Crossroads of Inflammation and Tumor ProgressionLuigi Mario Castello0Davide Raineri1Livia Salmi2Nausicaa Clemente3Rosanna Vaschetto4Marco Quaglia5Massimiliano Garzaro6Sergio Gentilli7Paolo Navalesi8Vincenzo Cantaluppi9Umberto Dianzani10Anna Aspesi11Annalisa Chiocchetti12Department of Translational Medicine, University of Eastern Piedmont, Novara, ItalyDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, ItalyDepartment of Translational Medicine, University of Eastern Piedmont, Novara, ItalyDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, ItalySCDU Anestesia e Rianimazione, Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, ItalyDepartment of Translational Medicine, Nephrology and Kidney Transplant Unit, University of Eastern Piedmont, Novara, ItalyDepartment of Health Sciences, University of Eastern Piedmont, Novara, ItalyDepartment of Surgery, University of Eastern Piedmont, Novara, ItalyAnestesia e Rianimazione, Università “Magna Graecia” di Catanzaro, Catanzaro, ItalyDepartment of Translational Medicine, Nephrology and Kidney Transplant Unit, University of Eastern Piedmont, Novara, ItalyDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, ItalyDepartment of Health Sciences, University of Eastern Piedmont, Novara, ItalyDepartment of Health Sciences and Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, ItalyComplex interactions between tumor and host cells regulate systemic tumor dissemination, a process that begins early at the primary tumor site and goes on until tumor cells detach themselves from the tumor mass and start migrating into the blood or lymphatic vessels. Metastatic cells colonize the target organs and are capable of surviving and growing at distant sites. In this context, osteopontin (OPN) appears to be a key determinant of the crosstalk between cancer cells and the host microenvironment, which in turn modulates immune evasion. OPN is overexpressed in several human carcinomas and has been implicated in inflammation, tumor progression, and metastasis. Thus, it represents one of the most attracting targets for cancer therapy. Within the tumor mass, OPN is secreted in various forms either by the tumor itself or by stroma cells, and it can exert either pro- or antitumorigenic effects according to the cell type and tumor microenvironment. Thus, targeting OPN for therapeutic purposes needs to take into account the heterogeneous functions of the multiple OPN forms with regard to cancer formation and progression. In this review, we will describe the role of systemic, tumor-derived, and stroma-derived OPN, highlighting its pivotal role at the crossroads of inflammation and tumor progression.http://dx.doi.org/10.1155/2017/4049098 |
| spellingShingle | Luigi Mario Castello Davide Raineri Livia Salmi Nausicaa Clemente Rosanna Vaschetto Marco Quaglia Massimiliano Garzaro Sergio Gentilli Paolo Navalesi Vincenzo Cantaluppi Umberto Dianzani Anna Aspesi Annalisa Chiocchetti Osteopontin at the Crossroads of Inflammation and Tumor Progression Mediators of Inflammation |
| title | Osteopontin at the Crossroads of Inflammation and Tumor Progression |
| title_full | Osteopontin at the Crossroads of Inflammation and Tumor Progression |
| title_fullStr | Osteopontin at the Crossroads of Inflammation and Tumor Progression |
| title_full_unstemmed | Osteopontin at the Crossroads of Inflammation and Tumor Progression |
| title_short | Osteopontin at the Crossroads of Inflammation and Tumor Progression |
| title_sort | osteopontin at the crossroads of inflammation and tumor progression |
| url | http://dx.doi.org/10.1155/2017/4049098 |
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