Uninephrectomized High-Fat-Fed Nicotinamide-Streptozotocin-Induced Diabetic Rats: A Model for the Investigation of Diabetic Nephropathy in Type 2 Diabetes

Uninephrectomized High-Fat-Fed Nicotinamide-Streptozotocin-Induced Diabetic Rats: A Model for the Investigation of Diabetic Nephropathy in Type 2 Diabetes

Type 2 diabetes (DM2) could be reproduced in rats with alimentary obesity by using low doses of streptozotocin (LD-STZ) as well as STZ in high doses with preliminary nicotinamide (NA) administration. However, STZ could induce tubulotoxicity. Aim. To develop rat model of DN in NA-STZ-induced DM2 and...

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Main Authors: Valentina K. Bayrasheva, Alina Yu. Babenko, Vladimir A. Dobronravov, Yuri V. Dmitriev, Svetlana G. Chefu, Ivan Yu. Pchelin, Alexandra N. Ivanova, Alekber A. Bairamov, Nina P. Alexeyeva, Ivan S. Shatalov, Elena N. Grineva
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2016/8317850
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