Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and C
Aim : To optimise the method of real-time elastography (RTE) in the assessment of liver fibrosis using an in-house prepared method for elastogram analysis, as well as a semiquantitative analysis based on newly introduced parameters. Material and methods : Sonoelastography was performed in 94 patie...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2016-07-01
|
| Series: | Gastroenterology Review |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Diagnostic-value-of-optimised-real-time-sonoelastography-in-the-assessment-of-liver-fibrosis-in-chronic-hepatitis-B-and-C,41,28069,1,1.html |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841548345748750336 |
|---|---|
| author | Katarzyna Kalita Krzysztof Filipczak Małgorzata Bieńkiewicz Wojciech Deroń Zbigniew Deroń Anna Piekarska Anna Płachcińska Jacek Kuśmierek |
| author_facet | Katarzyna Kalita Krzysztof Filipczak Małgorzata Bieńkiewicz Wojciech Deroń Zbigniew Deroń Anna Piekarska Anna Płachcińska Jacek Kuśmierek |
| author_sort | Katarzyna Kalita |
| collection | DOAJ |
| description | Aim : To optimise the method of real-time elastography (RTE) in the assessment of liver fibrosis using an in-house prepared method for elastogram analysis, as well as a semiquantitative analysis based on newly introduced parameters.
Material and methods : Sonoelastography was performed in 94 patients with various degrees of liver fibrosis and also in 25 healthy volunteers. As a reference method for diagnostic efficacy of sonoelastography-based parameters used for the assessment of fibrosis degree in patients with chronic B and C hepatitis, a liver biopsy was used. Patient’s elastograms were analysed using in-house prepared software, Pixel Count, calculating two semiquantitative parameters: mean stiffness fraction (MSF%) and intrinsic stiffness ratio (ISR).
Results: Statistically significant differences between distributions of the above presented parameters for different degrees of liver fibrosis were revealed. Indices of diagnostic efficacy for detection of significant liver fibrosis (F ≥ 2) using MSF% amounted to: sensitivity – 76%, specificity – 87% and ISR: 81% and 87%, respectively. Sensitivity of both parameters in detection of cirrhosis (F = 4) was equal to 88% and specificity amounted to: for MSF% – 84% and ISR – 86%. Interobserver reproducibility determined for both of the above parameters was high, intraclass correlation coefficients (ICC) were 0.91 for MSF% and 0.93 for ISR.
Conclusions : Real-time elastography applied in this study, using in-house prepared Pixel Count software, provided good reproducibility and diagnostic efficacy, especially specificity, in the assessment of liver fibrosis degree. |
| format | Article |
| id | doaj-art-ca11bd224e9445cb82c908b5ccf1bbc9 |
| institution | Kabale University |
| issn | 1895-5770 1897-4317 |
| language | English |
| publishDate | 2016-07-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Gastroenterology Review |
| spelling | doaj-art-ca11bd224e9445cb82c908b5ccf1bbc92025-01-10T14:06:16ZengTermedia Publishing HouseGastroenterology Review1895-57701897-43172016-07-01121283310.5114/pg.2016.6147528069Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and CKatarzyna KalitaKrzysztof FilipczakMałgorzata BieńkiewiczWojciech DerońZbigniew DerońAnna PiekarskaAnna PłachcińskaJacek KuśmierekAim : To optimise the method of real-time elastography (RTE) in the assessment of liver fibrosis using an in-house prepared method for elastogram analysis, as well as a semiquantitative analysis based on newly introduced parameters. Material and methods : Sonoelastography was performed in 94 patients with various degrees of liver fibrosis and also in 25 healthy volunteers. As a reference method for diagnostic efficacy of sonoelastography-based parameters used for the assessment of fibrosis degree in patients with chronic B and C hepatitis, a liver biopsy was used. Patient’s elastograms were analysed using in-house prepared software, Pixel Count, calculating two semiquantitative parameters: mean stiffness fraction (MSF%) and intrinsic stiffness ratio (ISR). Results: Statistically significant differences between distributions of the above presented parameters for different degrees of liver fibrosis were revealed. Indices of diagnostic efficacy for detection of significant liver fibrosis (F ≥ 2) using MSF% amounted to: sensitivity – 76%, specificity – 87% and ISR: 81% and 87%, respectively. Sensitivity of both parameters in detection of cirrhosis (F = 4) was equal to 88% and specificity amounted to: for MSF% – 84% and ISR – 86%. Interobserver reproducibility determined for both of the above parameters was high, intraclass correlation coefficients (ICC) were 0.91 for MSF% and 0.93 for ISR. Conclusions : Real-time elastography applied in this study, using in-house prepared Pixel Count software, provided good reproducibility and diagnostic efficacy, especially specificity, in the assessment of liver fibrosis degree.https://www.termedia.pl/Diagnostic-value-of-optimised-real-time-sonoelastography-in-the-assessment-of-liver-fibrosis-in-chronic-hepatitis-B-and-C,41,28069,1,1.htmlliver fibrosis real-time sonoelastography mean stiffness fraction intrinsic stiffness ratio |
| spellingShingle | Katarzyna Kalita Krzysztof Filipczak Małgorzata Bieńkiewicz Wojciech Deroń Zbigniew Deroń Anna Piekarska Anna Płachcińska Jacek Kuśmierek Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and C Gastroenterology Review liver fibrosis real-time sonoelastography mean stiffness fraction intrinsic stiffness ratio |
| title | Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and C |
| title_full | Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and C |
| title_fullStr | Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and C |
| title_full_unstemmed | Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and C |
| title_short | Diagnostic value of optimised real-time sonoelastography in the assessment of liver fibrosis in chronic hepatitis B and C |
| title_sort | diagnostic value of optimised real time sonoelastography in the assessment of liver fibrosis in chronic hepatitis b and c |
| topic | liver fibrosis real-time sonoelastography mean stiffness fraction intrinsic stiffness ratio |
| url | https://www.termedia.pl/Diagnostic-value-of-optimised-real-time-sonoelastography-in-the-assessment-of-liver-fibrosis-in-chronic-hepatitis-B-and-C,41,28069,1,1.html |
| work_keys_str_mv | AT katarzynakalita diagnosticvalueofoptimisedrealtimesonoelastographyintheassessmentofliverfibrosisinchronichepatitisbandc AT krzysztoffilipczak diagnosticvalueofoptimisedrealtimesonoelastographyintheassessmentofliverfibrosisinchronichepatitisbandc AT małgorzatabienkiewicz diagnosticvalueofoptimisedrealtimesonoelastographyintheassessmentofliverfibrosisinchronichepatitisbandc AT wojciechderon diagnosticvalueofoptimisedrealtimesonoelastographyintheassessmentofliverfibrosisinchronichepatitisbandc AT zbigniewderon diagnosticvalueofoptimisedrealtimesonoelastographyintheassessmentofliverfibrosisinchronichepatitisbandc AT annapiekarska diagnosticvalueofoptimisedrealtimesonoelastographyintheassessmentofliverfibrosisinchronichepatitisbandc AT annapłachcinska diagnosticvalueofoptimisedrealtimesonoelastographyintheassessmentofliverfibrosisinchronichepatitisbandc AT jacekkusmierek diagnosticvalueofoptimisedrealtimesonoelastographyintheassessmentofliverfibrosisinchronichepatitisbandc |