Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy
Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune posterior uveitis that can affect the visual function and, if left untreated, can lead to sight-threatening complications and loss of central vision. We performed a systematic search of the literature focused on visual electrophysiology...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2015/680215 |
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| author | Radouil Tzekov Brian Madow |
| author_facet | Radouil Tzekov Brian Madow |
| author_sort | Radouil Tzekov |
| collection | DOAJ |
| description | Birdshot chorioretinopathy (BSCR) is a rare form of autoimmune posterior uveitis that can affect the visual function and, if left untreated, can lead to sight-threatening complications and loss of central vision. We performed a systematic search of the literature focused on visual electrophysiology studies, including electroretinography (ERG), electrooculography (EOG), and visual evoked potentials (VEP), used to monitor the progression of BSCR and estimate treatment efficacy. Many reports were identified, including using a variety of methodologies and patient populations, which makes a direct comparison of the results difficult, especially with some of the earlier studies using nonstandardized methodology. Several different electrophysiological parameters, like EOG Arden’s ratio and the multifocal ERG response densities, are reported to be widely affected. However, informal consensus emerged in the past decade that the full-field ERG light-adapted 30 Hz flicker peak time is one of the most sensitive electrophysiological parameters. As such, it has been used widely in clinical trials to evaluate drug safety and efficacy and to guide therapeutic decisions in clinical practice. Despite its wide use, a well-designed longitudinal multicenter study to systematically evaluate and compare different electrophysiological methods or parameters in BSCR is still lacking but would benefit both diagnostic and therapeutic decisions. |
| format | Article |
| id | doaj-art-ca10b80a2fd94928afb65539154fc444 |
| institution | DOAJ |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-ca10b80a2fd94928afb65539154fc4442025-08-20T03:23:59ZengWileyJournal of Ophthalmology2090-004X2090-00582015-01-01201510.1155/2015/680215680215Visual Electrodiagnostic Testing in Birdshot ChorioretinopathyRadouil Tzekov0Brian Madow1Department of Ophthalmology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, P.O. Box MDC 21, Tampa, FL 33612, USADepartment of Ophthalmology, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Boulevard, P.O. Box MDC 21, Tampa, FL 33612, USABirdshot chorioretinopathy (BSCR) is a rare form of autoimmune posterior uveitis that can affect the visual function and, if left untreated, can lead to sight-threatening complications and loss of central vision. We performed a systematic search of the literature focused on visual electrophysiology studies, including electroretinography (ERG), electrooculography (EOG), and visual evoked potentials (VEP), used to monitor the progression of BSCR and estimate treatment efficacy. Many reports were identified, including using a variety of methodologies and patient populations, which makes a direct comparison of the results difficult, especially with some of the earlier studies using nonstandardized methodology. Several different electrophysiological parameters, like EOG Arden’s ratio and the multifocal ERG response densities, are reported to be widely affected. However, informal consensus emerged in the past decade that the full-field ERG light-adapted 30 Hz flicker peak time is one of the most sensitive electrophysiological parameters. As such, it has been used widely in clinical trials to evaluate drug safety and efficacy and to guide therapeutic decisions in clinical practice. Despite its wide use, a well-designed longitudinal multicenter study to systematically evaluate and compare different electrophysiological methods or parameters in BSCR is still lacking but would benefit both diagnostic and therapeutic decisions.http://dx.doi.org/10.1155/2015/680215 |
| spellingShingle | Radouil Tzekov Brian Madow Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy Journal of Ophthalmology |
| title | Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy |
| title_full | Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy |
| title_fullStr | Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy |
| title_full_unstemmed | Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy |
| title_short | Visual Electrodiagnostic Testing in Birdshot Chorioretinopathy |
| title_sort | visual electrodiagnostic testing in birdshot chorioretinopathy |
| url | http://dx.doi.org/10.1155/2015/680215 |
| work_keys_str_mv | AT radouiltzekov visualelectrodiagnostictestinginbirdshotchorioretinopathy AT brianmadow visualelectrodiagnostictestinginbirdshotchorioretinopathy |