Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study
Abstract The influence of functional gastrointestinal disorders (FGIDs) on the onset of Parkinson’s disease (PD) remains unclear. Therefore, in this study, we examined the effect of FGIDs and their subtypes on the PD onset. In Cox proportional hazards model, FGIDs significantly increased the risk of...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-01000-4 |
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| author | Yixiang Lin Haoling Xu Jiayi Zheng Tianxin Lin Minhui Wang Tingting Huang Fabin Lin Qinyong Ye Guoen Cai |
| author_facet | Yixiang Lin Haoling Xu Jiayi Zheng Tianxin Lin Minhui Wang Tingting Huang Fabin Lin Qinyong Ye Guoen Cai |
| author_sort | Yixiang Lin |
| collection | DOAJ |
| description | Abstract The influence of functional gastrointestinal disorders (FGIDs) on the onset of Parkinson’s disease (PD) remains unclear. Therefore, in this study, we examined the effect of FGIDs and their subtypes on the PD onset. In Cox proportional hazards model, FGIDs significantly increased the risk of PD incidence [hazard ratio (HR) = 1.74, 95% confidence interval (CI) = 1.30–2.33]. Similar results were also observed for functional dyspepsia (HR = 1.71, 95% CI = 1.17–2.52) and other functional intestinal disorders (other FIDs) (HR = 1.67, 95% CI = 1.00–2.78). Mediation analyses revealed that mental health scores mediated 10.00% and 8.32% of the association between FGIDs and functional dyspepsia and PD development. This cohort study discovered that FGIDs increase the risk of developing PD. Similar effects can also be observed in functional dyspepsia and other FIDs and mental health mediates part of the effect of FGIDs and functional dyspepsia on PD. |
| format | Article |
| id | doaj-art-ca0e98829f004d3d84b1d128b43b86d6 |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-ca0e98829f004d3d84b1d128b43b86d62025-08-20T03:26:42ZengNature Portfolionpj Parkinson's Disease2373-80572025-06-011111810.1038/s41531-025-01000-4Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort studyYixiang Lin0Haoling Xu1Jiayi Zheng2Tianxin Lin3Minhui Wang4Tingting Huang5Fabin Lin6Qinyong Ye7Guoen Cai8Department of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union HospitalDepartment of Neurology, Center for Cognitive Neurology, Institute of Clinical Neurology, Fujian Medical University Union HospitalAbstract The influence of functional gastrointestinal disorders (FGIDs) on the onset of Parkinson’s disease (PD) remains unclear. Therefore, in this study, we examined the effect of FGIDs and their subtypes on the PD onset. In Cox proportional hazards model, FGIDs significantly increased the risk of PD incidence [hazard ratio (HR) = 1.74, 95% confidence interval (CI) = 1.30–2.33]. Similar results were also observed for functional dyspepsia (HR = 1.71, 95% CI = 1.17–2.52) and other functional intestinal disorders (other FIDs) (HR = 1.67, 95% CI = 1.00–2.78). Mediation analyses revealed that mental health scores mediated 10.00% and 8.32% of the association between FGIDs and functional dyspepsia and PD development. This cohort study discovered that FGIDs increase the risk of developing PD. Similar effects can also be observed in functional dyspepsia and other FIDs and mental health mediates part of the effect of FGIDs and functional dyspepsia on PD.https://doi.org/10.1038/s41531-025-01000-4 |
| spellingShingle | Yixiang Lin Haoling Xu Jiayi Zheng Tianxin Lin Minhui Wang Tingting Huang Fabin Lin Qinyong Ye Guoen Cai Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study npj Parkinson's Disease |
| title | Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study |
| title_full | Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study |
| title_fullStr | Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study |
| title_full_unstemmed | Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study |
| title_short | Association between functional gastrointestinal disorders and Parkinson’s disease in a prospective cohort study |
| title_sort | association between functional gastrointestinal disorders and parkinson s disease in a prospective cohort study |
| url | https://doi.org/10.1038/s41531-025-01000-4 |
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