Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023)
<b>Introduction:</b> Invasive bacterial diseases (IBDs) such as meningitis and sepsis are significant public health concerns, particularly in pediatric populations. This study analyzes the incidence, outcomes, and bacterial serotype distribution of pediatric IBDs in the Veneto Region ove...
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2025-02-01
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| Online Access: | https://www.mdpi.com/2076-393X/13/3/230 |
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| author | Silvia Cocchio Claudia Cozzolino Andrea Cozza Patrizia Furlan Enrica Frasson Sara Tarantino Elisabetta Conte Lorenzo Chiusaroli Irene Amoruso Francesca Zanella Davide Gentili Michele Tonon Francesca Russo Tatjana Baldovin Vincenzo Baldo |
| author_facet | Silvia Cocchio Claudia Cozzolino Andrea Cozza Patrizia Furlan Enrica Frasson Sara Tarantino Elisabetta Conte Lorenzo Chiusaroli Irene Amoruso Francesca Zanella Davide Gentili Michele Tonon Francesca Russo Tatjana Baldovin Vincenzo Baldo |
| author_sort | Silvia Cocchio |
| collection | DOAJ |
| description | <b>Introduction:</b> Invasive bacterial diseases (IBDs) such as meningitis and sepsis are significant public health concerns, particularly in pediatric populations. This study analyzes the incidence, outcomes, and bacterial serotype distribution of pediatric IBDs in the Veneto Region over 17 years. <b>Methods:</b> An observational study was conducted using data (2007–2023) from the surveillance system of the Veneto Region, including microbiologically confirmed cases in individuals < 18 years. Differences by age groups and trends were statistically assessed. <b>Results:</b> A total of 535 pediatric IBD cases were reported, with <i>Streptococcus pneumoniae</i> (54.6%), <i>Neisseria meningitidis</i> (19.6%), and <i>Streptococcus agalactiae</i> (13.5%) being the most common pathogens. <i>Haemophilus influenzae</i> infections were more commonly represented in infants under 1 year (41.5%), whereas <i>S. pneumoniae</i> and <i>N. meningitidis</i> were more frequent in the 1–4-year age group (40.8% and 37.1%, respectively). Sepsis was the most common clinical presentation (57.2%), followed by meningitis (36.3%). Serotype analysis revealed that <i>S. pneumoniae</i> serotype 3 was the most prevalent, while serogroup B dominated <i>N. meningitidis</i> cases. Temporal trends generally showed a decline in cases until 2019, a drop during the COVID-19 pandemic, and a subsequent resurgence in 2022–2023. <b>Conclusions:</b> Our research underscores the value of evidence-based epidemiology through robust surveillance systems in tracking IBD trends and serotype shifts, essential for guiding vaccination strategies and public health interventions. These insights highlight the effectiveness of vaccination programs and the necessity of ongoing monitoring to inform public health policies. Improved data integration and completeness are recommended to enhance surveillance accuracy. |
| format | Article |
| id | doaj-art-ca0ac7c3a0484c5c9e10791f0fdea083 |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Vaccines |
| spelling | doaj-art-ca0ac7c3a0484c5c9e10791f0fdea0832025-08-20T03:43:55ZengMDPI AGVaccines2076-393X2025-02-0113323010.3390/vaccines13030230Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023)Silvia Cocchio0Claudia Cozzolino1Andrea Cozza2Patrizia Furlan3Enrica Frasson4Sara Tarantino5Elisabetta Conte6Lorenzo Chiusaroli7Irene Amoruso8Francesca Zanella9Davide Gentili10Michele Tonon11Francesca Russo12Tatjana Baldovin13Vincenzo Baldo14Department of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDivision of Pediatric Infectious Diseases, Department for Women’s and Children’s Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyRegional Directorate of Prevention, Food Safety, Veterinary, Public Health—Veneto Region, 30123 Venice, ItalyRegional Directorate of Prevention, Food Safety, Veterinary, Public Health—Veneto Region, 30123 Venice, ItalyRegional Directorate of Prevention, Food Safety, Veterinary, Public Health—Veneto Region, 30123 Venice, ItalyRegional Directorate of Prevention, Food Safety, Veterinary, Public Health—Veneto Region, 30123 Venice, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, ItalyDepartment of Cardiac, Thoracic, Vascular Sciences, and Public Health, University of Padua, 35128 Padua, Italy<b>Introduction:</b> Invasive bacterial diseases (IBDs) such as meningitis and sepsis are significant public health concerns, particularly in pediatric populations. This study analyzes the incidence, outcomes, and bacterial serotype distribution of pediatric IBDs in the Veneto Region over 17 years. <b>Methods:</b> An observational study was conducted using data (2007–2023) from the surveillance system of the Veneto Region, including microbiologically confirmed cases in individuals < 18 years. Differences by age groups and trends were statistically assessed. <b>Results:</b> A total of 535 pediatric IBD cases were reported, with <i>Streptococcus pneumoniae</i> (54.6%), <i>Neisseria meningitidis</i> (19.6%), and <i>Streptococcus agalactiae</i> (13.5%) being the most common pathogens. <i>Haemophilus influenzae</i> infections were more commonly represented in infants under 1 year (41.5%), whereas <i>S. pneumoniae</i> and <i>N. meningitidis</i> were more frequent in the 1–4-year age group (40.8% and 37.1%, respectively). Sepsis was the most common clinical presentation (57.2%), followed by meningitis (36.3%). Serotype analysis revealed that <i>S. pneumoniae</i> serotype 3 was the most prevalent, while serogroup B dominated <i>N. meningitidis</i> cases. Temporal trends generally showed a decline in cases until 2019, a drop during the COVID-19 pandemic, and a subsequent resurgence in 2022–2023. <b>Conclusions:</b> Our research underscores the value of evidence-based epidemiology through robust surveillance systems in tracking IBD trends and serotype shifts, essential for guiding vaccination strategies and public health interventions. These insights highlight the effectiveness of vaccination programs and the necessity of ongoing monitoring to inform public health policies. Improved data integration and completeness are recommended to enhance surveillance accuracy.https://www.mdpi.com/2076-393X/13/3/230pediatricmeningitissepsissurveillance system<i>Neisseria meningitidis</i><i>Streptococcus pneumoniae</i> |
| spellingShingle | Silvia Cocchio Claudia Cozzolino Andrea Cozza Patrizia Furlan Enrica Frasson Sara Tarantino Elisabetta Conte Lorenzo Chiusaroli Irene Amoruso Francesca Zanella Davide Gentili Michele Tonon Francesca Russo Tatjana Baldovin Vincenzo Baldo Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023) Vaccines pediatric meningitis sepsis surveillance system <i>Neisseria meningitidis</i> <i>Streptococcus pneumoniae</i> |
| title | Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023) |
| title_full | Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023) |
| title_fullStr | Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023) |
| title_full_unstemmed | Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023) |
| title_short | Surveillance of Pediatric Invasive Bacterial Diseases in the Veneto Region: Epidemiological Trends and Outcomes over 17 Years (2007–2023) |
| title_sort | surveillance of pediatric invasive bacterial diseases in the veneto region epidemiological trends and outcomes over 17 years 2007 2023 |
| topic | pediatric meningitis sepsis surveillance system <i>Neisseria meningitidis</i> <i>Streptococcus pneumoniae</i> |
| url | https://www.mdpi.com/2076-393X/13/3/230 |
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