Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind?
Cutaneous melanoma and uveal melanoma both derive from melanocytes but show remarkable differences in tumorigenesis, mode of metastatic spread, genetic alterations, and therapeutic response. In this review we discuss the differences and similarities along with the genetic research techniques availab...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/360136 |
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| _version_ | 1832554316938870784 |
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| author | Thomas van den Bosch Emine Kilic Dion Paridaens Annelies de Klein |
| author_facet | Thomas van den Bosch Emine Kilic Dion Paridaens Annelies de Klein |
| author_sort | Thomas van den Bosch |
| collection | DOAJ |
| description | Cutaneous melanoma and uveal melanoma both derive from melanocytes but show remarkable differences in tumorigenesis, mode of metastatic spread, genetic alterations, and therapeutic response. In this review we discuss the differences and similarities along with the genetic research techniques available and the contribution to our current understanding of melanoma. The several chromosomal aberrations already identified prove to be very strong predictors of decreased survival in CM and UM patients. Especially in UM, where the overall risk of metastasis is high (45%), genetic research might aid clinicians in selecting high-risk patients for future systemic adjuvant therapies. |
| format | Article |
| id | doaj-art-ca04fed665c74127b79b4223d2884d8f |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-ca04fed665c74127b79b4223d2884d8f2025-02-03T05:51:52ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/360136360136Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind?Thomas van den Bosch0Emine Kilic1Dion Paridaens2Annelies de Klein3Department of Ocular Oncology, The Rotterdam Eye Hospital, The NetherlandsDepartment of Ophthalmology, Erasmus Medical Center, P.O. Box 70030, 3000 LM Rotterdam, The NetherlandsDepartment of Ocular Oncology, The Rotterdam Eye Hospital, The NetherlandsDepartment of Clinical Genetics, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The NetherlandsCutaneous melanoma and uveal melanoma both derive from melanocytes but show remarkable differences in tumorigenesis, mode of metastatic spread, genetic alterations, and therapeutic response. In this review we discuss the differences and similarities along with the genetic research techniques available and the contribution to our current understanding of melanoma. The several chromosomal aberrations already identified prove to be very strong predictors of decreased survival in CM and UM patients. Especially in UM, where the overall risk of metastasis is high (45%), genetic research might aid clinicians in selecting high-risk patients for future systemic adjuvant therapies.http://dx.doi.org/10.1155/2010/360136 |
| spellingShingle | Thomas van den Bosch Emine Kilic Dion Paridaens Annelies de Klein Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind? Dermatology Research and Practice |
| title | Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind? |
| title_full | Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind? |
| title_fullStr | Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind? |
| title_full_unstemmed | Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind? |
| title_short | Genetics of Uveal Melanoma and Cutaneous Melanoma: Two of a Kind? |
| title_sort | genetics of uveal melanoma and cutaneous melanoma two of a kind |
| url | http://dx.doi.org/10.1155/2010/360136 |
| work_keys_str_mv | AT thomasvandenbosch geneticsofuvealmelanomaandcutaneousmelanomatwoofakind AT eminekilic geneticsofuvealmelanomaandcutaneousmelanomatwoofakind AT dionparidaens geneticsofuvealmelanomaandcutaneousmelanomatwoofakind AT anneliesdeklein geneticsofuvealmelanomaandcutaneousmelanomatwoofakind |