Influence of the Acetylation Type on the Incidence of Isoniazid-Induced Hepatotoxicity in Patients with Newly Diagnosed Pulmonary Tuberculosis

Influence of the Acetylation Type on the Incidence of Isoniazid-Induced Hepatotoxicity in Patients with Newly Diagnosed Pulmonary Tuberculosis

Introduction. Liver damage can be a dangerous side effect of using isoniazid. Individual susceptibility to isoniazid in humans is dependent on the presence of N-acetyltransferase 2 allelic variants in genome. It was imperative to assess the effect of genetically determined isoniazid acetylation rate...

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Bibliographic Details
Main Authors: N. M. Krasnova, N. E. Evdokimova, A. A. Egorova, O. I. Filippova, E. A. Alekseeva, Z. A. Rudykh, Ya. V. Chertovskykh, A. I. Vengerovskii, A. F. Kravchenko, D. A. Sychev
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2020-11-01
Series:Антибиотики и Химиотерапия
Subjects:
tuberculosis
isoniazid
n-acetyltransferase 2
acetylation types
hepatotoxicity
Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/751
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