Development and optimization of an innovative raft-forming antiemetic gastro-retentive system
Gastro-retentive drug delivery systems are vital for enhancing bioavailability and prolonging gastric residence time, especially for drugs with a short half-life like Ondansetron HCl. This study developed a raft-forming gastroretentive drug delivery system using a polyelectrolyte complex (PEC) of Ch...
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2025-04-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/147836/download/pdf/ |
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| _version_ | 1849700688563535872 |
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| author | Mina Safa Aziz Methaq Hamad Sabar |
| author_facet | Mina Safa Aziz Methaq Hamad Sabar |
| author_sort | Mina Safa Aziz |
| collection | DOAJ |
| description | Gastro-retentive drug delivery systems are vital for enhancing bioavailability and prolonging gastric residence time, especially for drugs with a short half-life like Ondansetron HCl. This study developed a raft-forming gastroretentive drug delivery system using a polyelectrolyte complex (PEC) of Chitosan and anionic polymers to improve stomach retention, regulate drug release, and enhance therapeutic efficacy. Various formulations were optimized based on polymer type, ratio, cross-linking agent concentration, and hydroxypropyl methylcellulose (HPMC K100M). The best formulation (F12: Chitosan: Carbopol 934) showed high entrapment efficiency (98%), drug loading (11.5%), buoyancy (>12 hours), extended drug release (over 12 hours), and a swelling ratio of 1584% at 8 hours. FTIR and DSC confirmed PEC formation and stability, while FE-SEM demonstrated homogeneity. Drug release followed non-Fickian kinetics, indicating that both diffusion and matrix relaxation contributed to the drug release. This PEC-based system shows promise for sustained stomach delivery of Ondansetron HCl, improving therapeutic efficacy and patient adherence. |
| format | Article |
| id | doaj-art-ca00c19f828e4b518695e04164cce972 |
| institution | DOAJ |
| issn | 2603-557X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj-art-ca00c19f828e4b518695e04164cce9722025-08-20T03:18:11ZengPensoft PublishersPharmacia2603-557X2025-04-017211410.3897/pharmacia.72.e147836147836Development and optimization of an innovative raft-forming antiemetic gastro-retentive systemMina Safa Aziz0Methaq Hamad Sabar1Mustansiriyah UniversityMustansiriyah UniversityGastro-retentive drug delivery systems are vital for enhancing bioavailability and prolonging gastric residence time, especially for drugs with a short half-life like Ondansetron HCl. This study developed a raft-forming gastroretentive drug delivery system using a polyelectrolyte complex (PEC) of Chitosan and anionic polymers to improve stomach retention, regulate drug release, and enhance therapeutic efficacy. Various formulations were optimized based on polymer type, ratio, cross-linking agent concentration, and hydroxypropyl methylcellulose (HPMC K100M). The best formulation (F12: Chitosan: Carbopol 934) showed high entrapment efficiency (98%), drug loading (11.5%), buoyancy (>12 hours), extended drug release (over 12 hours), and a swelling ratio of 1584% at 8 hours. FTIR and DSC confirmed PEC formation and stability, while FE-SEM demonstrated homogeneity. Drug release followed non-Fickian kinetics, indicating that both diffusion and matrix relaxation contributed to the drug release. This PEC-based system shows promise for sustained stomach delivery of Ondansetron HCl, improving therapeutic efficacy and patient adherence.https://pharmacia.pensoft.net/article/147836/download/pdf/ |
| spellingShingle | Mina Safa Aziz Methaq Hamad Sabar Development and optimization of an innovative raft-forming antiemetic gastro-retentive system Pharmacia |
| title | Development and optimization of an innovative raft-forming antiemetic gastro-retentive system |
| title_full | Development and optimization of an innovative raft-forming antiemetic gastro-retentive system |
| title_fullStr | Development and optimization of an innovative raft-forming antiemetic gastro-retentive system |
| title_full_unstemmed | Development and optimization of an innovative raft-forming antiemetic gastro-retentive system |
| title_short | Development and optimization of an innovative raft-forming antiemetic gastro-retentive system |
| title_sort | development and optimization of an innovative raft forming antiemetic gastro retentive system |
| url | https://pharmacia.pensoft.net/article/147836/download/pdf/ |
| work_keys_str_mv | AT minasafaaziz developmentandoptimizationofaninnovativeraftformingantiemeticgastroretentivesystem AT methaqhamadsabar developmentandoptimizationofaninnovativeraftformingantiemeticgastroretentivesystem |