The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease
Nutrition, the gut microbiota and immunity are all important factors in the maintenance of health. However, there is a growing realization of the complex interplay between these elements coalescing in a nutrition–gut microbiota–immunity axis. This regulatory axis is critical for health with disrupti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/2/329 |
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| author | Samantha L. Dawson Emma Todd Alister C. Ward |
| author_facet | Samantha L. Dawson Emma Todd Alister C. Ward |
| author_sort | Samantha L. Dawson |
| collection | DOAJ |
| description | Nutrition, the gut microbiota and immunity are all important factors in the maintenance of health. However, there is a growing realization of the complex interplay between these elements coalescing in a nutrition–gut microbiota–immunity axis. This regulatory axis is critical for health with disruption being implicated in a broad range of diseases, including autoimmune disorders, allergies and mental health disorders. This new perspective continues to underpin a growing number of innovative therapeutic strategies targeting different elements of this axis to treat relevant diseases. This review describes the inter-relationships between nutrition, the gut microbiota and immunity. It then details several human diseases where disruption of the nutrition–gut microbiota–immunity axis has been identified and presents examples of how the various elements may be targeted therapeutically as alternate treatment strategies for these diseases. |
| format | Article |
| id | doaj-art-ca005cd777f64987a404651c7dc53b96 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-ca005cd777f64987a404651c7dc53b962025-08-20T02:44:34ZengMDPI AGBiomedicines2227-90592025-01-0113232910.3390/biomedicines13020329The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human DiseaseSamantha L. Dawson0Emma Todd1Alister C. Ward2School of Medicine, Deakin University, Waurn Ponds, VIC 3216, AustraliaSchool of Medicine, Deakin University, Waurn Ponds, VIC 3216, AustraliaSchool of Medicine, Deakin University, Waurn Ponds, VIC 3216, AustraliaNutrition, the gut microbiota and immunity are all important factors in the maintenance of health. However, there is a growing realization of the complex interplay between these elements coalescing in a nutrition–gut microbiota–immunity axis. This regulatory axis is critical for health with disruption being implicated in a broad range of diseases, including autoimmune disorders, allergies and mental health disorders. This new perspective continues to underpin a growing number of innovative therapeutic strategies targeting different elements of this axis to treat relevant diseases. This review describes the inter-relationships between nutrition, the gut microbiota and immunity. It then details several human diseases where disruption of the nutrition–gut microbiota–immunity axis has been identified and presents examples of how the various elements may be targeted therapeutically as alternate treatment strategies for these diseases.https://www.mdpi.com/2227-9059/13/2/329allergyautoimmune diseasegutimmunityinflammationmental health disorders |
| spellingShingle | Samantha L. Dawson Emma Todd Alister C. Ward The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease Biomedicines allergy autoimmune disease gut immunity inflammation mental health disorders |
| title | The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease |
| title_full | The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease |
| title_fullStr | The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease |
| title_full_unstemmed | The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease |
| title_short | The Interplay of Nutrition, the Gut Microbiota and Immunity and Its Contribution to Human Disease |
| title_sort | interplay of nutrition the gut microbiota and immunity and its contribution to human disease |
| topic | allergy autoimmune disease gut immunity inflammation mental health disorders |
| url | https://www.mdpi.com/2227-9059/13/2/329 |
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