A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites
BackgroundMetabolites derived from the gut microbiota are substantial contributors to the pathophysiology of Irritable Bowel Syndrome (IBS). As our understanding of the mechanisms underlying gut microbiota metabolites advances, significant progress has been made in research exploring the correlation...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1559926/full |
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| author | Shi-Ran Wang Shi-Ran Wang Jie Zhou Jia-Yi Zhang Shi-Fang Li Guo-Jie Hu |
| author_facet | Shi-Ran Wang Shi-Ran Wang Jie Zhou Jia-Yi Zhang Shi-Fang Li Guo-Jie Hu |
| author_sort | Shi-Ran Wang |
| collection | DOAJ |
| description | BackgroundMetabolites derived from the gut microbiota are substantial contributors to the pathophysiology of Irritable Bowel Syndrome (IBS). As our understanding of the mechanisms underlying gut microbiota metabolites advances, significant progress has been made in research exploring the correlation between gut microbiota metabolites and IBS. Nevertheless, a comprehensive synthesis of research foci and trends in this domain is still lacking. Consequently, integrating scientometric methods with a range of analytical tools can facilitate the identification of key research areas and potential future study directions.MethodsThe present study employed scientometric tools, including VOSviewer, Bibliometrix software, CiteSpace, Tableau, and R software, to collect and analyze research literature on IBS and gut microbiota metabolites. This comprised an analysis of journal publications and their impact, the identification of prolific authors, the establishment of national research collaboration networks, and the co-occurrence analysis of keywords.ResultsThe analysis revealed that, following screening, a total of 1,489 documents were obtained, with a gradual increase in the number of publications starting from 2006. The United States, China, and the United Kingdom have been identified as the primary hubs of this research field. The leading research institutions were identified as University College Cork, the Mayo Clinic, and the University of California. In the domain of research under discussion, John F. Cryan, Timothy G. Dinan, and Gerard Clarke are the most prominent authors. Multiple analyses of the keywords revealed that research on gut microbiota metabolites in irritable bowel syndrome primarily focuses on the functions and mechanisms of action of specific metabolites (1). Emerging research hotspots on gut microbial metabolites influencing IBS are centered on bile acids. In contrast, chain fatty acids have been the most studied metabolites in past research. (2) Gut microbiota metabolites primarily affect IBS through the critical role of the gut-brain axis and are closely associated with anxiety-like behaviors. (3) Experimental types related to gut microbiota metabolites and IBS research.ConclusionThis study employed bibliometric analysis to map the knowledge structure and identify research hotspots in gut microbiota metabolites and IBS, providing insights for future studies. |
| format | Article |
| id | doaj-art-c9fedb0fbe9a412c85f86cd9c72ff46b |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-c9fedb0fbe9a412c85f86cd9c72ff46b2025-08-20T04:00:10ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-08-011610.3389/fmicb.2025.15599261559926A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolitesShi-Ran Wang0Shi-Ran Wang1Jie Zhou2Jia-Yi Zhang3Shi-Fang Li4Guo-Jie Hu5Department of Traditional Chinese Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaQingdao Medical College, Qingdao University, Qingdao, Shandong, ChinaQingdao Medical College, Qingdao University, Qingdao, Shandong, ChinaDepartment of Traditional Chinese Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, ChinaDepartment of Neurosurgery, Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao Medical College, Qingdao University, Qingdao, Shandong, ChinaBackgroundMetabolites derived from the gut microbiota are substantial contributors to the pathophysiology of Irritable Bowel Syndrome (IBS). As our understanding of the mechanisms underlying gut microbiota metabolites advances, significant progress has been made in research exploring the correlation between gut microbiota metabolites and IBS. Nevertheless, a comprehensive synthesis of research foci and trends in this domain is still lacking. Consequently, integrating scientometric methods with a range of analytical tools can facilitate the identification of key research areas and potential future study directions.MethodsThe present study employed scientometric tools, including VOSviewer, Bibliometrix software, CiteSpace, Tableau, and R software, to collect and analyze research literature on IBS and gut microbiota metabolites. This comprised an analysis of journal publications and their impact, the identification of prolific authors, the establishment of national research collaboration networks, and the co-occurrence analysis of keywords.ResultsThe analysis revealed that, following screening, a total of 1,489 documents were obtained, with a gradual increase in the number of publications starting from 2006. The United States, China, and the United Kingdom have been identified as the primary hubs of this research field. The leading research institutions were identified as University College Cork, the Mayo Clinic, and the University of California. In the domain of research under discussion, John F. Cryan, Timothy G. Dinan, and Gerard Clarke are the most prominent authors. Multiple analyses of the keywords revealed that research on gut microbiota metabolites in irritable bowel syndrome primarily focuses on the functions and mechanisms of action of specific metabolites (1). Emerging research hotspots on gut microbial metabolites influencing IBS are centered on bile acids. In contrast, chain fatty acids have been the most studied metabolites in past research. (2) Gut microbiota metabolites primarily affect IBS through the critical role of the gut-brain axis and are closely associated with anxiety-like behaviors. (3) Experimental types related to gut microbiota metabolites and IBS research.ConclusionThis study employed bibliometric analysis to map the knowledge structure and identify research hotspots in gut microbiota metabolites and IBS, providing insights for future studies.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1559926/fullgut microbiotagut microbiota metabolitesIBSbibliometric analysisresearch progressresearch trend |
| spellingShingle | Shi-Ran Wang Shi-Ran Wang Jie Zhou Jia-Yi Zhang Shi-Fang Li Guo-Jie Hu A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites Frontiers in Microbiology gut microbiota gut microbiota metabolites IBS bibliometric analysis research progress research trend |
| title | A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites |
| title_full | A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites |
| title_fullStr | A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites |
| title_full_unstemmed | A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites |
| title_short | A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites |
| title_sort | bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites |
| topic | gut microbiota gut microbiota metabolites IBS bibliometric analysis research progress research trend |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1559926/full |
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