Prognostic nutritional index is a better inflammation based prognostic marker in elderly patients with hepatocellular carcinoma after surgery
Abstract The role of inflammation-related markers in patients with elderly hepatocellular carcinoma (HCC) is not well known. This study aimed to evaluate and compare the prognostic value of various inflammation-related markers in elderly HCC patients after radical resection.350 elderly HCC patients...
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Nature Portfolio
2025-08-01
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| Online Access: | https://doi.org/10.1038/s41598-025-12158-5 |
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| author | Qionglan Wu Jinhua Zeng Jianxing Zeng |
| author_facet | Qionglan Wu Jinhua Zeng Jianxing Zeng |
| author_sort | Qionglan Wu |
| collection | DOAJ |
| description | Abstract The role of inflammation-related markers in patients with elderly hepatocellular carcinoma (HCC) is not well known. This study aimed to evaluate and compare the prognostic value of various inflammation-related markers in elderly HCC patients after radical resection.350 elderly HCC patients after radical resection were included. Survival rate and prognostic analysis were using Kaplan-Meier and Cox regression analysis. The prognostic value of inflammation-related markers was compared by C-index and time-dependent receiver operating characteristic curve (AUC). Propensity score matching (PSM) was used for patient selection to minimize bias. The C-index and time-dependent AUC showed that PNI was higher than the other inflammation-related markers. After PSM, the 1-year, 3-year, and 5-year overall survival rates in the low prognostic nutritional index (PNI) and high PNI groups were 83.3%, 69.5%, 51.5%, and 95.0%, 87.8%, 71.3% (p = 0.047), respectively. The 1-year, 3-year, and 5-year recurrence-free survival rates in the two groups were 63.3%, 47.8%, 24.5%, and 86.7%, 76.3%, 57.1% (p < 0.001), respectively. Multivariate Cox regression revealed that PNI was the independent risk factor associated with death (p = 0.016, HR = 0.552) and tumor recurrence (p = 0.001, HR = 0.432). PNI was a better inflammation-based prognostic marker in elderly HCC patients after radical resection. This simple marker could help physicians determine elder HCC patients at high risk of tumor recurrence for frequent clinical surveillance. |
| format | Article |
| id | doaj-art-c9febc4128984f0db8f999feef5fe6b0 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-c9febc4128984f0db8f999feef5fe6b02025-08-24T11:18:02ZengNature PortfolioScientific Reports2045-23222025-08-0115111110.1038/s41598-025-12158-5Prognostic nutritional index is a better inflammation based prognostic marker in elderly patients with hepatocellular carcinoma after surgeryQionglan Wu0Jinhua Zeng1Jianxing Zeng2Department of Pathology, Mengchao Hepatobiliary Hospital of Fujian Medical UniversityDepartment of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical UniversityDepartment of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical UniversityAbstract The role of inflammation-related markers in patients with elderly hepatocellular carcinoma (HCC) is not well known. This study aimed to evaluate and compare the prognostic value of various inflammation-related markers in elderly HCC patients after radical resection.350 elderly HCC patients after radical resection were included. Survival rate and prognostic analysis were using Kaplan-Meier and Cox regression analysis. The prognostic value of inflammation-related markers was compared by C-index and time-dependent receiver operating characteristic curve (AUC). Propensity score matching (PSM) was used for patient selection to minimize bias. The C-index and time-dependent AUC showed that PNI was higher than the other inflammation-related markers. After PSM, the 1-year, 3-year, and 5-year overall survival rates in the low prognostic nutritional index (PNI) and high PNI groups were 83.3%, 69.5%, 51.5%, and 95.0%, 87.8%, 71.3% (p = 0.047), respectively. The 1-year, 3-year, and 5-year recurrence-free survival rates in the two groups were 63.3%, 47.8%, 24.5%, and 86.7%, 76.3%, 57.1% (p < 0.001), respectively. Multivariate Cox regression revealed that PNI was the independent risk factor associated with death (p = 0.016, HR = 0.552) and tumor recurrence (p = 0.001, HR = 0.432). PNI was a better inflammation-based prognostic marker in elderly HCC patients after radical resection. This simple marker could help physicians determine elder HCC patients at high risk of tumor recurrence for frequent clinical surveillance.https://doi.org/10.1038/s41598-025-12158-5Hepatocellular carcinomaElderlyPrognostic nutritional index (PNI)Liver resectionPrognosis |
| spellingShingle | Qionglan Wu Jinhua Zeng Jianxing Zeng Prognostic nutritional index is a better inflammation based prognostic marker in elderly patients with hepatocellular carcinoma after surgery Scientific Reports Hepatocellular carcinoma Elderly Prognostic nutritional index (PNI) Liver resection Prognosis |
| title | Prognostic nutritional index is a better inflammation based prognostic marker in elderly patients with hepatocellular carcinoma after surgery |
| title_full | Prognostic nutritional index is a better inflammation based prognostic marker in elderly patients with hepatocellular carcinoma after surgery |
| title_fullStr | Prognostic nutritional index is a better inflammation based prognostic marker in elderly patients with hepatocellular carcinoma after surgery |
| title_full_unstemmed | Prognostic nutritional index is a better inflammation based prognostic marker in elderly patients with hepatocellular carcinoma after surgery |
| title_short | Prognostic nutritional index is a better inflammation based prognostic marker in elderly patients with hepatocellular carcinoma after surgery |
| title_sort | prognostic nutritional index is a better inflammation based prognostic marker in elderly patients with hepatocellular carcinoma after surgery |
| topic | Hepatocellular carcinoma Elderly Prognostic nutritional index (PNI) Liver resection Prognosis |
| url | https://doi.org/10.1038/s41598-025-12158-5 |
| work_keys_str_mv | AT qionglanwu prognosticnutritionalindexisabetterinflammationbasedprognosticmarkerinelderlypatientswithhepatocellularcarcinomaaftersurgery AT jinhuazeng prognosticnutritionalindexisabetterinflammationbasedprognosticmarkerinelderlypatientswithhepatocellularcarcinomaaftersurgery AT jianxingzeng prognosticnutritionalindexisabetterinflammationbasedprognosticmarkerinelderlypatientswithhepatocellularcarcinomaaftersurgery |