Assessing dermal exposure to organochlorine pesticides in different populations of a prototypical agricultural city in South China
Abstract Persistent organic pollutants have been widely detected in the environment and pose a substantial threat to human health. However, few studies have directly investigated exposure to organochlorine pesticides (OCPs) through skin contact. Therefore, we aimed to evaluate dermal exposure to OCP...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-04-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-87961-1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849734820735746048 |
|---|---|
| author | Jian Guo Xiaojun Luo Yanhong Zeng Bixian Mai |
| author_facet | Jian Guo Xiaojun Luo Yanhong Zeng Bixian Mai |
| author_sort | Jian Guo |
| collection | DOAJ |
| description | Abstract Persistent organic pollutants have been widely detected in the environment and pose a substantial threat to human health. However, few studies have directly investigated exposure to organochlorine pesticides (OCPs) through skin contact. Therefore, we aimed to evaluate dermal exposure to OCPs in different populations in a typical agricultural city in South China. Skin wipe samples were collected from the faces, hands, forearms, and shanks of 120 volunteers (50% male and 50% female) across various age groups. All ten target OCPs were detected in the samples, with concentrations ranging from non-detectable (ND) to 7200 ng/m2. The concentration of OCPs displayed a consistent pattern of face > hand > forearm > shank regardless of age or sex. Daily average doses of dermal ingestion (DADderm) and hand-to-mouth contact ingestion (DADoral) ranged from ND to 68 ng/kg/d and from ND to 7.8 ng/kg/d, respectively. Hexachlorocyclohexane (HCH) was the primary contributor, accounting for 68% of the DADderm and 91% of the DADoral. No significant age- or sex-based differences were observed in DADderm, but DADoral showed significant variation, being markedly higher in preschoolers than in other age groups and higher in females than in males. Carcinogenic risks associated with OCPs dermal exposure ranged from ND to 2.4 × 10− 5, with older adults facing the highest risk and females having significantly higher risk than males. |
| format | Article |
| id | doaj-art-c9f869500bf64e39b5e5ec06c86485bf |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-c9f869500bf64e39b5e5ec06c86485bf2025-08-20T03:07:41ZengNature PortfolioScientific Reports2045-23222025-04-011511910.1038/s41598-025-87961-1Assessing dermal exposure to organochlorine pesticides in different populations of a prototypical agricultural city in South ChinaJian Guo0Xiaojun Luo1Yanhong Zeng2Bixian Mai3Guangdong University of Petrochemical TechnologyState Key Laboratory of Advanced Environmental Technology, Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of SciencesState Key Laboratory of Advanced Environmental Technology, Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of SciencesState Key Laboratory of Advanced Environmental Technology, Guangdong Provincial Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of SciencesAbstract Persistent organic pollutants have been widely detected in the environment and pose a substantial threat to human health. However, few studies have directly investigated exposure to organochlorine pesticides (OCPs) through skin contact. Therefore, we aimed to evaluate dermal exposure to OCPs in different populations in a typical agricultural city in South China. Skin wipe samples were collected from the faces, hands, forearms, and shanks of 120 volunteers (50% male and 50% female) across various age groups. All ten target OCPs were detected in the samples, with concentrations ranging from non-detectable (ND) to 7200 ng/m2. The concentration of OCPs displayed a consistent pattern of face > hand > forearm > shank regardless of age or sex. Daily average doses of dermal ingestion (DADderm) and hand-to-mouth contact ingestion (DADoral) ranged from ND to 68 ng/kg/d and from ND to 7.8 ng/kg/d, respectively. Hexachlorocyclohexane (HCH) was the primary contributor, accounting for 68% of the DADderm and 91% of the DADoral. No significant age- or sex-based differences were observed in DADderm, but DADoral showed significant variation, being markedly higher in preschoolers than in other age groups and higher in females than in males. Carcinogenic risks associated with OCPs dermal exposure ranged from ND to 2.4 × 10− 5, with older adults facing the highest risk and females having significantly higher risk than males.https://doi.org/10.1038/s41598-025-87961-1Organochlorine pesticideSkin wipe sampleDermal exposureCarcinogenic risk |
| spellingShingle | Jian Guo Xiaojun Luo Yanhong Zeng Bixian Mai Assessing dermal exposure to organochlorine pesticides in different populations of a prototypical agricultural city in South China Scientific Reports Organochlorine pesticide Skin wipe sample Dermal exposure Carcinogenic risk |
| title | Assessing dermal exposure to organochlorine pesticides in different populations of a prototypical agricultural city in South China |
| title_full | Assessing dermal exposure to organochlorine pesticides in different populations of a prototypical agricultural city in South China |
| title_fullStr | Assessing dermal exposure to organochlorine pesticides in different populations of a prototypical agricultural city in South China |
| title_full_unstemmed | Assessing dermal exposure to organochlorine pesticides in different populations of a prototypical agricultural city in South China |
| title_short | Assessing dermal exposure to organochlorine pesticides in different populations of a prototypical agricultural city in South China |
| title_sort | assessing dermal exposure to organochlorine pesticides in different populations of a prototypical agricultural city in south china |
| topic | Organochlorine pesticide Skin wipe sample Dermal exposure Carcinogenic risk |
| url | https://doi.org/10.1038/s41598-025-87961-1 |
| work_keys_str_mv | AT jianguo assessingdermalexposuretoorganochlorinepesticidesindifferentpopulationsofaprototypicalagriculturalcityinsouthchina AT xiaojunluo assessingdermalexposuretoorganochlorinepesticidesindifferentpopulationsofaprototypicalagriculturalcityinsouthchina AT yanhongzeng assessingdermalexposuretoorganochlorinepesticidesindifferentpopulationsofaprototypicalagriculturalcityinsouthchina AT bixianmai assessingdermalexposuretoorganochlorinepesticidesindifferentpopulationsofaprototypicalagriculturalcityinsouthchina |