Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains

Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains

Occult hepatitis B virus infection (OBI) is a low-level asymptomatic phase of HBV infection. Evidence of OBI clinical relevance is emerging but the mechanisms of its occurrence remain unclear. In this study, the molecular characteristics of 97 confirmed OBI from Chinese blood donors were analyzed an...

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Bibliographic Details
Main Authors: Lu Zhang, Le Chang, Syria Laperche, Huimin Ji, Junpeng Zhao, Xinyi Jiang, Lunan Wang, Daniel Candotti
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Hepatitis B virus
occult infection
N-linked glycosylation
transmembrane domain
blood donors
HBsAg
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1663130
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